{"id":"W3119631312","doi":"10.1101/2021.01.08.425953","title":"Decoupling of global brain activity and cerebrospinal fluid flow in Parkinson’s cognitive decline","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cerebrospinal fluid; Montreal Cognitive Assessment; Parkinson's disease; Neuroscience; Psychology; Cognitive decline; Cardiology; Internal medicine; Resting state fMRI; Medicine; Cognition; Cerebral blood flow; Dementia; Disease; Cognitive impairment","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003675748,0.0003810277,0.0003631687,0.000924708,0.0002163214,0.000400872,0.0001631898,0.0002543765,0.0008315405],"category_scores_gemma":[0.001138415,0.0001356904,0.0001487041,0.0004402528,0.0003309753,0.0002696048,0.0003830576,0.0002510273,0.00009131941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002224586,"about_ca_system_score_gemma":0.0001362217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002609095,"about_ca_topic_score_gemma":0.002745443,"domain_scores_codex":[0.999916,0.00001862406,0.000008380779,0.00002116187,0.00002111123,0.00001479951],"domain_scores_gemma":[0.9994654,0.0001058737,0.0002340364,0.00002697757,0.00007341879,0.00009436144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002284559,0.0001422774,0.9702737,0.00005844824,0.0002583483,0.0004966691,0.0003823172,0.0002853109,0.01344145,0.00004039783,0.0001078681,0.01222863],"study_design_scores_gemma":[0.000008116126,0.0001321999,0.9989298,0.000002828248,0.00001911546,0.0002046506,0.00005869884,0.0002033396,0.0003490636,0.00005337419,0.00003640123,0.000002405611],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994549,0.0001624254,0.00009471152,0.000009308433,0.000001144325,0.000003554459,0.00005420288,0.000002532454,0.0002171803],"genre_scores_gemma":[0.9997322,0.00004106454,0.0000718899,0.000006282293,0.000003230941,0.000002893551,0.0000690434,7.064467e-7,0.000072686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002609095,"threshold_uncertainty_score":0.00518775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825458095563966,"score_gpt":0.2574575750485195,"score_spread":0.2392029940928798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}