{"id":"W3119663175","doi":"10.1042/bcj20200773","title":"Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner","year":2021,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Dysferlin; Calcium; Chemistry; Calcium-binding protein; EF hand; Biophysics; Binding domain; Membrane protein; Binding site; Biochemistry; Membrane; Cell biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001864102,0.0001190795,0.0001264774,0.000023128,0.0001054603,0.00003493517,0.0001389416,0.0001792785,0.00004822461],"category_scores_gemma":[0.00008681318,0.00008205627,0.00007383012,0.00008191934,0.0001785004,0.000003184447,0.0001096699,0.0002556936,0.00000373505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000863728,"about_ca_system_score_gemma":0.00009407382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007177759,"about_ca_topic_score_gemma":0.00001379905,"domain_scores_codex":[0.999175,0.00009532516,0.0001904105,0.000218845,0.00008980984,0.000230575],"domain_scores_gemma":[0.9996125,0.00002368587,0.00004673314,0.0001717175,0.00005492086,0.00009050433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489946,0.00006369382,0.001244247,0.000006909571,0.00003306589,0.00003135856,0.00004558003,0.000003939931,0.9917451,0.0001908231,0.006234089,0.0002521815],"study_design_scores_gemma":[0.00318413,0.0002459957,0.02086302,0.00005150095,0.00003420096,0.0007680352,0.001080967,0.0001306389,0.9274539,0.006206926,0.03949701,0.0004836168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929541,0.003361347,0.000221188,0.002941061,0.0001094109,0.00004378667,0.000003771965,0.000003343531,0.0003619465],"genre_scores_gemma":[0.9977531,0.0004141823,0.000242084,0.001066745,0.0002679873,0.000006392789,0.00002851328,0.000009553639,0.0002114836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06429116,"threshold_uncertainty_score":0.3346158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009391990167763292,"score_gpt":0.248926721052975,"score_spread":0.2395347308852117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}