{"id":"W3119663175","doi":"10.1042/bcj20200773","title":"Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner","year":2021,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Dysferlin; Calcium; Chemistry; Calcium-binding protein; EF hand; Biophysics; Binding domain; Membrane protein; Binding site; Biochemistry; Membrane; Cell biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408319,0.0003244724,0.0003636116,0.0001396091,0.0004840428,0.000396596,0.0006197459,0.0004111451,0.001436351],"category_scores_gemma":[0.0002644745,0.0002725932,0.0001995481,0.0001502543,0.0004011184,0.0002838025,0.0005485686,0.0004811996,0.0003229349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006289932,"about_ca_system_score_gemma":0.0003701012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002457349,"about_ca_topic_score_gemma":0.002987606,"domain_scores_codex":[0.9998218,0.00002356108,0.000008468015,0.00005500522,0.00005278084,0.00003837592],"domain_scores_gemma":[0.999874,0.00002410578,0.00003694791,0.00001169645,0.00001742238,0.0000358235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002707886,0.00005412906,0.0008729692,0.00009233023,0.00003125996,0.0002815831,0.00008705486,0.0006719798,0.9946038,0.0005012673,0.0002167028,0.002316008],"study_design_scores_gemma":[0.0003228402,0.0005163782,0.03411881,0.00007040804,0.00008406481,0.001312053,0.0002570428,0.01928121,0.9258955,0.001097598,0.01693361,0.0001104268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956288,0.0007688605,0.00179858,0.000172638,0.00003124229,0.00002043908,0.00006261244,0.00004791167,0.001469006],"genre_scores_gemma":[0.9963546,0.000255388,0.001639321,0.0001459724,0.00001119938,0.00002066918,0.0001394388,0.00001231134,0.001421145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002457349,"threshold_uncertainty_score":0.004886031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009391990167763292,"score_gpt":0.248926721052975,"score_spread":0.2395347308852117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}