{"id":"W3119693776","doi":"10.1016/j.bbr.2020.113101","title":"Roles of inflammation in intrinsic pathophysiology and antipsychotic drug-induced metabolic disturbances of schizophrenia","year":2021,"lang":"en","type":"review","venue":"Behavioural Brain Research","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Diabetes Canada; University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Aging; Centre for Addiction and Mental Health; National Institutes of Health; University of Toronto; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Banting and Best Diabetes Centre, University of Toronto; U.S. Department of Defense","keywords":"Schizophrenia (object-oriented programming); Antipsychotic; Psychosis; Disease; Inflammation; Medicine; Psychiatry; Systemic inflammation; Metabolic syndrome; Management of schizophrenia; Antipsychotic drug; Mechanism (biology); Psychology; Neuroscience; Bioinformatics; Internal medicine; Obesity; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001027602,0.0003259783,0.001680107,0.001003689,0.00008362366,0.00004638674,0.0006179052,0.0002670333,0.00003055183],"category_scores_gemma":[0.001977106,0.0002675364,0.0002581448,0.00196439,0.0006043312,0.0001510032,0.000343609,0.0009234134,0.000007620769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003308037,"about_ca_system_score_gemma":0.0003602734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001381787,"about_ca_topic_score_gemma":0.0002516223,"domain_scores_codex":[0.9945811,0.002544585,0.0009202758,0.0007647741,0.0006726225,0.0005166365],"domain_scores_gemma":[0.9970151,0.001856813,0.0003771872,0.0005210898,0.0001333657,0.00009641255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004154898,0.0001323165,0.000161722,0.002832148,0.00001085971,0.00003657683,0.0002400278,1.400467e-7,0.02274771,0.002219412,0.00006602829,0.9715115],"study_design_scores_gemma":[0.02174723,0.003156742,0.2262429,0.1374095,0.001128096,0.0004251298,0.00544089,0.00009819844,0.3141681,0.01366577,0.2676483,0.008869209],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4205448,0.5786126,1.732172e-7,0.00008462919,0.00007384589,0.0006071033,0.00003656537,0.000009904049,0.00003036289],"genre_scores_gemma":[0.1895004,0.8101808,0.00003074501,0.000009650447,0.00004668733,0.00009389195,0.00003158786,0.00003343125,0.00007286309],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9626423,"threshold_uncertainty_score":0.9999777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.144864106099696,"score_gpt":0.4077791471116648,"score_spread":0.2629150410119688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}