{"id":"W3119695715","doi":"10.1016/j.molcel.2020.12.010","title":"CARM1 regulates replication fork speed and stress response by stimulating PARP1","year":2021,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Université de Montréal; Centre hospitalier universitaire de Québec","funders":"National Institute of General Medical Sciences; Biotechnology and Biological Sciences Research Council; Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; Cancer Research UK; Wellcome Trust","keywords":"Biology; PARP1; DNA replication; Fork (system call); Cell biology; Replication (statistics); DNA damage; Genetics; DNA; Poly ADP ribose polymerase; Polymerase; Computer science; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003359734,0.0005531573,0.0004192095,0.0005588567,0.0006572423,0.001211973,0.0009365465,0.0008296608,0.005969614],"category_scores_gemma":[0.0005715085,0.0005247394,0.0005828525,0.0003119251,0.000541073,0.0007688957,0.0007333093,0.001763317,0.001844413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00187647,"about_ca_system_score_gemma":0.00053165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001338898,"about_ca_topic_score_gemma":0.001990508,"domain_scores_codex":[0.9995062,0.00004292374,0.00002234875,0.0001783727,0.0001020876,0.0001479114],"domain_scores_gemma":[0.9994113,0.00009865833,0.0001479102,0.00007362086,0.0001040755,0.0001643679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004940366,0.0001032114,0.0009552184,0.00008566941,0.00001491637,0.00006711584,0.00002732042,0.0001867037,0.9925542,0.0008697055,0.000777239,0.003864663],"study_design_scores_gemma":[0.00003585354,0.0001759005,0.01335434,0.00001103995,0.00001843353,0.0001696902,0.0000749899,0.002268697,0.9740113,0.0002285352,0.009631282,0.00001992555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9597771,0.009686153,0.01301901,0.002396886,0.0005497613,0.0001031079,0.002768833,0.001239633,0.01045954],"genre_scores_gemma":[0.9871386,0.0009199645,0.003379574,0.000322861,0.00005646467,0.00007095649,0.001575122,0.0001494864,0.006386877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005969614,"threshold_uncertainty_score":0.01997036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005927424538897505,"score_gpt":0.232182323980153,"score_spread":0.2262548994412555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}