{"id":"W3119695715","doi":"10.1016/j.molcel.2020.12.010","title":"CARM1 regulates replication fork speed and stress response by stimulating PARP1","year":2021,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Université de Montréal; Centre hospitalier universitaire de Québec","funders":"National Institute of General Medical Sciences; Biotechnology and Biological Sciences Research Council; Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; Cancer Research UK; Wellcome Trust","keywords":"Biology; PARP1; DNA replication; Fork (system call); Cell biology; Replication (statistics); DNA damage; Genetics; DNA; Poly ADP ribose polymerase; Polymerase; Computer science; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002525676,0.0001500094,0.0001274697,0.00002113761,0.00006899943,0.00004366582,0.0001087641,0.0001540704,0.00001064616],"category_scores_gemma":[0.0001977472,0.0001759616,0.00006847983,0.00008766149,0.00003469616,0.000003256385,0.0001653207,0.00007062409,0.000004932651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001374834,"about_ca_system_score_gemma":0.00005067757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006615518,"about_ca_topic_score_gemma":0.000002391285,"domain_scores_codex":[0.9986497,0.0001762627,0.0001818617,0.0006309324,0.0001378774,0.0002233883],"domain_scores_gemma":[0.9988834,0.00002041483,0.00007542063,0.0008326524,0.00009329111,0.00009478004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001053824,0.00004204734,0.0004540851,0.00002058996,0.00002081779,0.00003572791,0.00003226659,0.0001527566,0.9973403,0.00002708104,0.0006224975,0.001146427],"study_design_scores_gemma":[0.000445653,0.0001384526,0.0002752337,0.00001472329,0.00002174937,0.00001607491,0.00006527422,0.0005166385,0.9877992,0.0001048289,0.01040428,0.0001978693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935693,0.002347409,0.002693491,0.0002104669,0.00004737988,0.0001602823,0.00004238446,0.00002790541,0.0009014452],"genre_scores_gemma":[0.9933857,0.00004403268,0.003495143,0.0003359134,0.00002736488,0.000009553585,0.0004047611,0.00003983704,0.002257713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009781785,"threshold_uncertainty_score":0.7175506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005927424538897505,"score_gpt":0.232182323980153,"score_spread":0.2262548994412555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}