{"id":"W3119702262","doi":"10.1039/d0ra06994a","title":"The design, synthesis, and <i>in vitro</i> trypanocidal and leishmanicidal activities of 1,3-thiazole and 4-thiazolidinone ester derivatives","year":2021,"lang":"en","type":"article","venue":"RSC Advances","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre","funders":"Centro de Tecnologias Estratégicas do Nordeste; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Trypanosoma cruzi; Amastigote; Thiazole; Leishmania infantum; Cytotoxicity; Leishmania; Chemistry; IC50; Leishmaniasis; Chagas disease; In vitro; Pharmacology; Biochemistry; Biology; Stereochemistry; Parasite hosting; Immunology; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002467118,0.0003798753,0.0001674535,0.0001868351,0.0001974654,0.0003122471,0.0004992592,0.0003056125,0.001746019],"category_scores_gemma":[0.0002293149,0.000153955,0.0002807929,0.000252518,0.0002061792,0.000321167,0.0002319819,0.0005813077,0.0007614495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003534964,"about_ca_system_score_gemma":0.0005622231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001346831,"about_ca_topic_score_gemma":0.001563052,"domain_scores_codex":[0.9998994,0.00002309304,0.00001292917,0.00001424837,0.00001920138,0.00003116352],"domain_scores_gemma":[0.9999448,0.000006302672,0.00001820201,0.000006404746,0.00001432672,0.000009964466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003515245,0.000264233,0.0002334044,0.000848634,0.00002811492,0.0005358386,0.0001965234,0.00371255,0.9517663,0.006251044,0.002039165,0.03377272],"study_design_scores_gemma":[0.00009313979,0.002431261,0.000899662,0.0000402044,0.00004262368,0.0005543968,0.00006349698,0.00183171,0.9529428,0.0004229728,0.04063154,0.00004618165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8866552,0.02853768,0.04046974,0.002085732,0.0005433513,0.0005739505,0.002090384,0.0003257416,0.03871816],"genre_scores_gemma":[0.9552997,0.01779743,0.01497434,0.0003373588,0.00008659844,0.0001536912,0.001285685,0.00004584241,0.0100194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001746019,"threshold_uncertainty_score":0.005841076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02407813564306695,"score_gpt":0.293575569951912,"score_spread":0.2694974343088451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}