{"id":"W3119702262","doi":"10.1039/d0ra06994a","title":"The design, synthesis, and <i>in vitro</i> trypanocidal and leishmanicidal activities of 1,3-thiazole and 4-thiazolidinone ester derivatives","year":2021,"lang":"en","type":"article","venue":"RSC Advances","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre","funders":"Centro de Tecnologias Estratégicas do Nordeste; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Trypanosoma cruzi; Amastigote; Thiazole; Leishmania infantum; Cytotoxicity; Leishmania; Chemistry; IC50; Leishmaniasis; Chagas disease; In vitro; Pharmacology; Biochemistry; Biology; Stereochemistry; Parasite hosting; Immunology; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003237968,0.0001751456,0.0004604655,0.00006537715,0.0002003197,0.00005686242,0.0000609284,0.00005379134,0.000005626864],"category_scores_gemma":[0.0007297618,0.0001194264,0.00003235787,0.0001486954,0.0007403395,0.0003193932,0.0001812431,0.0001933928,4.345743e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002243774,"about_ca_system_score_gemma":0.00007843864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001526484,"about_ca_topic_score_gemma":0.00008361391,"domain_scores_codex":[0.9986501,0.0001934972,0.0002514955,0.0003199693,0.0002787402,0.0003062225],"domain_scores_gemma":[0.9976704,0.001886886,0.00008725915,0.0001900902,0.00008259659,0.00008282336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001859283,0.000173083,0.03501553,0.0007038147,0.0002737678,0.0001620327,0.002715634,0.000004697539,0.8307845,0.0006183808,0.0001374442,0.1275519],"study_design_scores_gemma":[0.001038671,0.00016628,0.08414837,0.0002118964,0.00005365945,0.0001922695,0.008488186,0.0001126794,0.9014478,0.000989361,0.002977296,0.0001735081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9367293,0.05898396,0.0002454919,0.00293584,0.00004697381,0.0002859914,0.000008449663,0.00001708345,0.0007469082],"genre_scores_gemma":[0.9662237,0.0302749,0.00298422,0.0001112289,0.00004675528,0.00005829247,9.695389e-7,0.0000171065,0.0002828044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1273783,"threshold_uncertainty_score":0.4870066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02407813564306695,"score_gpt":0.293575569951912,"score_spread":0.2694974343088451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}