{"id":"W3119704901","doi":"10.1186/s13041-020-00725-y","title":"A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels","year":2021,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Trigeminal neuralgia; Gating; Neuroscience; Psychopharmacology; Trigeminal nerve; Medicine; Psychology; Anesthesia; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000150728,0.001173376,0.0004564375,0.000697425,0.0004964849,0.0003160202,0.0004128703,0.001456146,0.002691461],"category_scores_gemma":[0.0009055565,0.000169613,0.0004015132,0.0004415496,0.0007597068,0.0002319258,0.0002901207,0.0006379635,0.0003263347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002916669,"about_ca_system_score_gemma":0.0002102498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182429,"about_ca_topic_score_gemma":0.0008220733,"domain_scores_codex":[0.9997273,0.00002975004,0.00002969585,0.00009697046,0.00006609545,0.00005015963],"domain_scores_gemma":[0.9996111,0.0001354309,0.0001052261,0.00002614843,0.0000212646,0.0001008841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008646501,0.0002565672,0.03604209,0.0001256406,0.0001480773,0.381097,0.0006212217,0.0009513724,0.5696378,0.001240238,0.0005444553,0.008470874],"study_design_scores_gemma":[0.0001867086,0.001186625,0.2453844,0.00007834692,0.0002239403,0.6574078,0.0004450106,0.005796866,0.08536651,0.001223805,0.002598498,0.000101537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983084,0.0001459159,0.0006347286,0.000108858,0.00005160386,0.0000164413,0.000113911,0.00003081953,0.0005891951],"genre_scores_gemma":[0.999464,0.00002745612,0.0002015061,0.00003440109,0.00002643534,0.000003414951,0.00003907862,0.000006041972,0.0001976648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002691461,"threshold_uncertainty_score":0.009003818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00938499961516489,"score_gpt":0.2260062628727909,"score_spread":0.216621263257626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}