{"id":"W3119720084","doi":"10.1101/2021.01.06.425580","title":"The H3K36me2 writer-reader dependency in H3K27M-DIPG","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Making Headway Foundation; National Cancer Institute; National Institutes of Health; Alex's Lemonade Stand Foundation for Childhood Cancer; Deutsche Forschungsgemeinschaft; York University; American Cancer Society; National Institute of Neurological Disorders and Stroke; Hyundai Hope On Wheels; New York State Stem Cell Science; NYU Grossman School of Medicine; Howard Hughes Medical Institute","keywords":"Histone H3; Histone; Biology; Epigenetics; Chromatin; Carcinogenesis; Methylation; Cell biology; Cancer research; Chemistry; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070381,0.0001796807,0.00015454,0.0001151223,0.0001211226,0.0001065362,0.0001978657,0.0001992454,0.001771552],"category_scores_gemma":[0.00008880266,0.0001258779,0.0001975793,0.00008597433,0.0002286898,0.00008369174,0.0001532983,0.0004073676,0.0003228204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389032,"about_ca_system_score_gemma":0.0001439483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001403075,"about_ca_topic_score_gemma":0.001890673,"domain_scores_codex":[0.999887,0.00001383993,0.000008514687,0.00002600135,0.0000384969,0.00002621475],"domain_scores_gemma":[0.9999118,0.00001658123,0.00002190607,0.00001000107,0.000008863631,0.00003083322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007689582,0.000007343594,0.00008626242,0.00001244761,0.000002377225,0.00002231105,0.000002881096,0.00001827652,0.9995288,0.00001470194,0.00001133605,0.0002165298],"study_design_scores_gemma":[0.000006615,0.0001182045,0.002613331,9.178463e-7,0.000003291457,0.000119287,0.000007260322,0.0002938573,0.9962474,0.00001118611,0.0005765647,0.000002026771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967331,0.0007386922,0.001217538,0.00007624809,0.00001928582,0.00002191316,0.0003380707,0.0000340722,0.0008211985],"genre_scores_gemma":[0.9972167,0.0001822075,0.0007532638,0.00004087649,0.000003145003,0.0000151452,0.0003815324,0.000009156801,0.001397953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001771552,"threshold_uncertainty_score":0.005926371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236616138496573,"score_gpt":0.2340073698886373,"score_spread":0.2216412085036716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}