{"id":"W3119721218","doi":"10.1007/s10875-020-00933-0","title":"IFN-α2a Therapy in Two Patients with Inborn Errors of TLR3 and IRF3 Infected with SARS-CoV-2","year":2021,"lang":"en","type":"letter","venue":"Journal of Clinical Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Mercatus Center, George Mason University; Hospital for Sick Children; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; St. Giles Foundation; George Mason University; Fisher Center for Alzheimer's Research Foundation; National Institutes of Health; Yale University; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Agence Nationale de la Recherche; Georgia Clinical and Translational Science Alliance; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Medicine; Virology; Medical microbiology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; IRF3; Fulminant; Immunology; Pathology; Outbreak; Infectious disease (medical specialty); Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005840259,0.001250065,0.000975331,0.0005506331,0.00178049,0.001156318,0.0008437146,0.008298863,0.001803747],"category_scores_gemma":[0.005041602,0.0004911111,0.001271439,0.0003348304,0.000978241,0.0008348619,0.0005748725,0.004533299,0.0004708273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001571786,"about_ca_system_score_gemma":0.0007731278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002437101,"about_ca_topic_score_gemma":0.002300374,"domain_scores_codex":[0.9993777,0.0001272138,0.00009451869,0.0001078817,0.00007175163,0.0002209903],"domain_scores_gemma":[0.9978698,0.0009468481,0.0002300527,0.0001044009,0.0001357332,0.0007131076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0004617741,0.0001699674,0.009460799,0.00003606953,0.0000355697,0.9802491,0.0002595842,0.000122091,0.001263948,0.0004909366,0.003830283,0.003619851],"study_design_scores_gemma":[0.0003620148,0.001025333,0.01647134,0.0000954891,0.0001011332,0.9699073,0.0005715929,0.001318906,0.001674036,0.00113757,0.00729333,0.00004191501],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8494074,0.003436792,0.00226461,0.1146949,0.00777841,0.0001760132,0.0002976826,0.000135761,0.0218085],"genre_scores_gemma":[0.9520379,0.001353362,0.001399203,0.03340143,0.005263514,0.00005709767,0.0001199787,0.00004884563,0.006318639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008298863,"threshold_uncertainty_score":0.01140416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03485580265394161,"score_gpt":0.3378840962575282,"score_spread":0.3030282936035866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}