{"id":"W3119728301","doi":"10.1101/2021.01.09.426034","title":"Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Institutes of Health; Wellcome Trust","keywords":"Innate immune system; Immunology; Immune system; Inflammation; IRF7; RNA silencing; Biology; Disease; Cognitive decline; Neuroscience; RNA; Medicine; RNA interference; Gene; Dementia; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001076263,0.0004500219,0.0001758451,0.0001808666,0.00007037886,0.0001786595,0.0001078331,0.0002017244,0.0008464221],"category_scores_gemma":[0.00007350648,0.0001230336,0.0001657239,0.0000691736,0.0002404362,0.0001808109,0.00009491327,0.0004758588,0.0002075836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001947972,"about_ca_system_score_gemma":0.000117371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001971737,"about_ca_topic_score_gemma":0.0003869957,"domain_scores_codex":[0.9999268,0.000008771708,0.000008556092,0.00002493191,0.00001428451,0.00001656659],"domain_scores_gemma":[0.9998221,0.00001407677,0.0000955151,0.00001321985,0.00001145297,0.00004376045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007808675,0.00002117802,0.00009493052,0.0000147951,0.000001744959,0.00001445601,0.000004945217,0.00001696193,0.9993737,0.00001716083,0.000007892433,0.0003541237],"study_design_scores_gemma":[0.00002469779,0.0018838,0.009434888,0.000009753636,0.00002138647,0.0002836682,0.00002022364,0.0004291672,0.9871045,0.00004977024,0.0007341093,0.00000397654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997239,0.0007923575,0.001122655,0.00004375371,0.00001299566,0.00002178075,0.0002364137,0.00006567816,0.0004654182],"genre_scores_gemma":[0.994305,0.0008696212,0.001786664,0.0000647793,0.00001559446,0.00006177247,0.0003812441,0.00001875666,0.002496474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008464221,"threshold_uncertainty_score":0.002831519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0127099205529357,"score_gpt":0.234978390424167,"score_spread":0.2222684698712313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}