{"id":"W3119770690","doi":"10.3390/v13010070","title":"TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway","year":2021,"lang":"en","type":"article","venue":"Viruses","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"IRF3; Herpes simplex virus; Biology; ISG15; Interferon; Downregulation and upregulation; Virology; Viral replication; Cell culture; Intrinsic immunity; Virus; Immunology; Gene; Immunity; Immune system; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001622336,0.000170189,0.0002212285,0.00004311751,0.0003568884,0.0000608205,0.00003470051,0.00008722606,0.0002633995],"category_scores_gemma":[0.000391577,0.000110663,0.0001267139,0.0003609949,0.0001070567,0.0002222497,0.00004126023,0.0001650572,0.0002223066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000687268,"about_ca_system_score_gemma":0.000130366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001082577,"about_ca_topic_score_gemma":0.0001031994,"domain_scores_codex":[0.9988464,0.0002146791,0.0002439027,0.0002693389,0.0001902457,0.000235413],"domain_scores_gemma":[0.9991344,0.0003240788,0.00006378703,0.0003403944,0.00009365234,0.00004369448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006440147,0.00186092,0.3865694,0.0001282241,0.0009727909,0.0002903135,0.002477557,0.00002314047,0.3162914,0.001692091,0.01776834,0.2712818],"study_design_scores_gemma":[0.001127357,0.0002154679,0.0379232,0.00007589711,0.0001040792,0.00007515797,0.0002342867,0.00001470691,0.359401,0.0003105931,0.6003693,0.0001489106],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896577,0.001338081,0.0002551085,0.0005081948,0.0002303548,0.0002223964,0.0001154513,0.0001546881,0.007518008],"genre_scores_gemma":[0.9951006,0.0002497404,0.0002634566,0.0008679013,0.0001111989,0.00004406645,0.00004040546,0.00002146181,0.003301184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.582601,"threshold_uncertainty_score":0.4512706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04818238925760788,"score_gpt":0.3289060531003647,"score_spread":0.2807236638427569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}