{"id":"W3119770690","doi":"10.3390/v13010070","title":"TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway","year":2021,"lang":"en","type":"article","venue":"Viruses","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"IRF3; Herpes simplex virus; Biology; ISG15; Interferon; Downregulation and upregulation; Virology; Viral replication; Cell culture; Intrinsic immunity; Virus; Immunology; Gene; Immunity; Immune system; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001856967,0.0002576578,0.000263562,0.0002021609,0.0002215009,0.0003782133,0.0002521088,0.0003436306,0.002789358],"category_scores_gemma":[0.0001235487,0.0001211726,0.000413792,0.000100055,0.0002204854,0.0002346695,0.0002780612,0.000789726,0.000933449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002181809,"about_ca_system_score_gemma":0.0001915058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000414312,"about_ca_topic_score_gemma":0.0005350242,"domain_scores_codex":[0.9998507,0.00002218197,0.00001298473,0.00003131131,0.00003255365,0.00005025225],"domain_scores_gemma":[0.9998944,0.00001132244,0.00002811472,0.00001552521,0.00001302802,0.00003765593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001946615,0.00003736912,0.0004551136,0.00009959691,0.000005818216,0.00008037194,0.00002366496,0.00007808875,0.9972829,0.0001052756,0.0001834208,0.001453829],"study_design_scores_gemma":[0.0000345697,0.0004713856,0.01184956,0.00003415276,0.00003367619,0.0006317089,0.0001415425,0.001260349,0.9758153,0.00009318444,0.009621342,0.00001321857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885218,0.003005805,0.00287277,0.0003105422,0.00009229442,0.00004771424,0.001217764,0.0003016487,0.003629756],"genre_scores_gemma":[0.991538,0.001114128,0.002611216,0.0001346393,0.00001921168,0.00004257675,0.001214417,0.00003575863,0.003289822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002789358,"threshold_uncertainty_score":0.009331286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04818238925760788,"score_gpt":0.3289060531003647,"score_spread":0.2807236638427569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}