{"id":"W3119812808","doi":"10.25251/skin.5.supp.15","title":"Bimekizumab Efficacy and Safety versus Adalimumab in Patients with Moderate to Severe Plaque Psoriasis: Results from a Multicenter, Randomized, Double-Blinded Active Comparator-Controlled Phase 3 Trial (BE SURE)","year":2021,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Probity Medical Research","funders":"UCB Pharma; European Academy of Dermatology and Venereology","keywords":"Medicine; Adalimumab; Plaque psoriasis; Double blinded; Multicenter study; Randomized controlled trial; Psoriasis; Internal medicine; Dermatology; Pathology; Placebo; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001051827,0.0003949821,0.001995478,0.0002131031,0.0001886487,0.00002056044,0.0002505169,0.0002149399,0.0001381649],"category_scores_gemma":[0.0009052262,0.000209548,0.0001672389,0.0002579486,0.0002268862,0.00009579289,0.00005358492,0.0004848982,0.000009361826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001412228,"about_ca_system_score_gemma":0.0002567686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00024376,"about_ca_topic_score_gemma":0.0003935746,"domain_scores_codex":[0.9959202,0.001822016,0.00131818,0.0003270335,0.0002453655,0.00036724],"domain_scores_gemma":[0.9929818,0.005235908,0.000892191,0.0003465213,0.000433754,0.0001098115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9822502,0.001356174,0.00001348236,0.000004575444,0.003889935,0.0003510431,0.005616577,0.0003315484,0.0006247316,0.000009238737,0.0003727782,0.005179698],"study_design_scores_gemma":[0.98716,0.004643722,0.0001339493,0.000329196,0.00243525,0.0003583305,0.001038127,0.00003256128,0.003218076,0.00002149828,0.0004102019,0.0002190669],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917649,0.002090025,0.00005248867,0.00150737,0.002051014,0.002128485,0.0002029833,0.00001291998,0.0001898023],"genre_scores_gemma":[0.9985331,0.0005756876,0.00008278493,0.000156014,0.0002737205,0.00002077482,0.0001862478,0.00002493156,0.0001467703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006768156,"threshold_uncertainty_score":0.8545119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02438267293933946,"score_gpt":0.2821770173124763,"score_spread":0.2577943443731369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}