{"id":"W3119830444","doi":"10.1007/s12022-021-09663-4","title":"Genomics and Epigenomics of Pituitary Tumors: What Do Pathologists Need to Know?","year":2021,"lang":"en","type":"review","venue":"Endocrine Pathology","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"MEN1; GNAS complex locus; Pituitary tumors; Epigenetics; Epigenomics; Biology; Cancer research; Pathology; Molecular pathology; Multiple endocrine neoplasia; Bioinformatics; Medicine; Gene; DNA methylation; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001589027,0.0007911058,0.002075502,0.001543051,0.0002538992,0.001851362,0.001163538,0.001703767,0.00320664],"category_scores_gemma":[0.002499984,0.0003005152,0.0006796492,0.001800954,0.0007334852,0.002377694,0.0008339878,0.00270419,0.001328347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008121088,"about_ca_system_score_gemma":0.002107851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001959841,"about_ca_topic_score_gemma":0.003536899,"domain_scores_codex":[0.9996842,0.00008858171,0.0000416277,0.00005108677,0.0001001111,0.00003446129],"domain_scores_gemma":[0.9982573,0.001102213,0.0001515231,0.00004544173,0.0003407113,0.0001027763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009523054,0.00003766015,0.0005517629,0.01392231,0.0002271971,0.000260378,0.00007769392,0.0003339833,0.0008343314,0.004539223,0.05828566,0.9208346],"study_design_scores_gemma":[0.00002695701,0.00006339791,0.001692059,0.007930659,0.0003354895,0.001202261,0.0001356477,0.0001264591,0.0002288489,0.004911471,0.9833103,0.00003654839],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004632666,0.9979665,0.0001051793,0.001298672,0.0002455258,0.000001559202,0.0000192173,0.000005305724,0.0003116874],"genre_scores_gemma":[0.0003869952,0.9979469,0.0001891281,0.0008317285,0.0004311269,0.00000317838,0.00002904567,0.000001225744,0.0001805916],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00320664,"threshold_uncertainty_score":0.01072729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02869491749237026,"score_gpt":0.329021484659597,"score_spread":0.3003265671672268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}