{"id":"W3119949981","doi":"10.1073/pnas.2009988118","title":"Citramalate synthase yields a biosynthetic pathway for isoleucine and straight- and branched-chain ester formation in ripening apple fruit","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada","funders":"Agriculture and Agri-Food Canada; U.S. Department of Agriculture; National Institute of Food and Agriculture; National Science Foundation","keywords":"Ripening; Isoleucine; Biosynthesis; Chemistry; Biochemistry; ATP synthase; Biology; Stereochemistry; Food science; Enzyme; Leucine; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124553,0.0002812983,0.0001746517,0.0001234757,0.0001704458,0.0004254011,0.0001540013,0.0002368933,0.0005960361],"category_scores_gemma":[0.0001262878,0.0001464589,0.0002222313,0.00009319293,0.0002256307,0.0002913206,0.0002506567,0.0004327606,0.0003467317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005955492,"about_ca_system_score_gemma":0.0003482224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000819264,"about_ca_topic_score_gemma":0.001350533,"domain_scores_codex":[0.9999015,0.00001231535,0.000008860059,0.00003350422,0.00002944101,0.00001439031],"domain_scores_gemma":[0.9999082,0.00001748684,0.00001709056,0.000016386,0.00001194908,0.00002894962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003793221,0.000008399443,0.0004330577,0.00001556304,0.000001881038,0.00005034103,0.0000148069,0.0000870259,0.9981844,0.0001970025,0.00001309481,0.0009563665],"study_design_scores_gemma":[0.000004294497,0.00006878702,0.007489181,0.00000376062,0.000005851709,0.0003248291,0.00002828686,0.001102922,0.9890644,0.0001147935,0.00178661,0.000006375476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885978,0.0008850219,0.007464387,0.0001021087,0.00002620647,0.00002426727,0.0004385334,0.0001320875,0.00232962],"genre_scores_gemma":[0.9911787,0.0003468122,0.004543831,0.0000441119,0.000005533133,0.00001092165,0.001028341,0.00003349967,0.002808303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000819264,"threshold_uncertainty_score":0.004321098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0241535250127266,"score_gpt":0.2602403862364469,"score_spread":0.2360868612237203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}