{"id":"W3119982255","doi":"10.1002/bies.202000269","title":"What deubiquitinating enzymes, oncogenes, and tumor suppressors actually do: Are current assumptions supported by patient outcomes?","year":2021,"lang":"en","type":"review","venue":"BioEssays","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Deubiquitinating enzyme; Suppressor; Oncogene; Biology; Crosstalk; Tumor suppressor gene; Context (archaeology); Cancer research; Gene; Tumor microenvironment; Carcinogenesis; Cell biology; Ubiquitin; Genetics; Tumor cells; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002769242,0.0006633378,0.001964496,0.001474412,0.0002439645,0.00152044,0.001102324,0.001630186,0.001998643],"category_scores_gemma":[0.005540577,0.0002404215,0.0006557347,0.001457434,0.001350005,0.002851753,0.000602838,0.002650729,0.001436531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009722395,"about_ca_system_score_gemma":0.001583892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001103144,"about_ca_topic_score_gemma":0.001955113,"domain_scores_codex":[0.9992604,0.0002251193,0.0001267137,0.0001124519,0.0002313455,0.00004394391],"domain_scores_gemma":[0.9968179,0.002365436,0.0002051193,0.00008793279,0.0004511616,0.00007240276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001411709,0.00003569574,0.0006244592,0.01605818,0.0002108429,0.0002190687,0.00009634451,0.0003431512,0.0008036749,0.01483557,0.03119922,0.9354325],"study_design_scores_gemma":[0.00002551692,0.00011892,0.001771446,0.01620569,0.0002637326,0.0020396,0.0002601492,0.0001218408,0.0005112833,0.01821071,0.9604315,0.00003974316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009683377,0.996659,0.0001735102,0.001893222,0.0002933718,0.000002330961,0.00002451018,0.000004655677,0.000852494],"genre_scores_gemma":[0.001131186,0.9969254,0.0002352293,0.001060192,0.0003076514,0.00000590607,0.00002970432,0.00000283235,0.0003018276],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002769242,"threshold_uncertainty_score":0.01464534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03808144184257165,"score_gpt":0.32736386618947,"score_spread":0.2892824243468983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}