{"id":"W3119982255","doi":"10.1002/bies.202000269","title":"What deubiquitinating enzymes, oncogenes, and tumor suppressors actually do: Are current assumptions supported by patient outcomes?","year":2021,"lang":"en","type":"review","venue":"BioEssays","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Deubiquitinating enzyme; Suppressor; Oncogene; Biology; Crosstalk; Tumor suppressor gene; Context (archaeology); Cancer research; Gene; Tumor microenvironment; Carcinogenesis; Cell biology; Ubiquitin; Genetics; Tumor cells; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003375667,0.0008518736,0.001511773,0.0001228673,0.0002425797,0.0004001833,0.0004280508,0.0005466359,0.0002460491],"category_scores_gemma":[0.000297158,0.0007320309,0.0006019874,0.0001834757,0.0001327729,0.00002127156,0.0006605937,0.0004735999,0.00002728401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006876602,"about_ca_system_score_gemma":0.0004478481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007076784,"about_ca_topic_score_gemma":0.00001411312,"domain_scores_codex":[0.9963678,0.0004869029,0.0009018568,0.001204371,0.0003851367,0.0006539073],"domain_scores_gemma":[0.997703,0.0001029798,0.000839792,0.000822358,0.0002007223,0.0003311225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006383616,0.0002231481,0.0001170639,0.004796769,0.00037116,0.00005299122,0.0001003764,1.599569e-7,0.0008261682,0.0000861304,0.02142704,0.9719926],"study_design_scores_gemma":[0.0002916194,0.0001374443,0.000006730301,0.005932136,0.0003781482,0.0001118473,0.0003019758,9.223518e-7,0.006299249,0.000007603281,0.9856898,0.0008424915],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0018137,0.9938973,0.00004066467,0.00004907927,0.001013788,0.001004717,0.00193199,0.00004536317,0.000203411],"genre_scores_gemma":[0.0005800899,0.9914746,0.0002061467,0.0001863929,0.0002429913,0.0004714695,0.006307113,0.0001311561,0.0004000934],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9711501,"threshold_uncertainty_score":0.9995131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03808144184257165,"score_gpt":0.32736386618947,"score_spread":0.2892824243468983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}