{"id":"W3119986140","doi":"10.14336/ad.2020.0624","title":"Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a","year":2021,"lang":"en","type":"article","venue":"Aging and Disease","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Mesenchymal stem cell; Microvesicles; Hydrogen peroxide; Senescence; Wound healing; Medicine; Stem cell; Cell; Cell biology; Cancer research; microRNA; Chemistry; Immunology; Pathology; Biology; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002085118,0.0002240243,0.0003521098,0.0002120375,0.0001005523,0.0003070535,0.0001409595,0.000237618,0.001473596],"category_scores_gemma":[0.0001724702,0.0001709538,0.0004107885,0.0001271699,0.0002312516,0.0003138889,0.0001798266,0.0005567326,0.0002996175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001212096,"about_ca_system_score_gemma":0.0002062041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002305318,"about_ca_topic_score_gemma":0.0002498478,"domain_scores_codex":[0.9998546,0.00003287543,0.0000239243,0.00002842335,0.00002450127,0.00003560124],"domain_scores_gemma":[0.9999088,0.00001291728,0.00003035835,0.00001586872,0.00001001431,0.00002197773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006501491,0.0001094488,0.0002202818,0.00006804899,0.00001717766,0.00003031607,0.00001708163,0.00004051407,0.996375,0.00009586786,0.00007404797,0.002301922],"study_design_scores_gemma":[0.00006038829,0.0009258157,0.006237931,0.000006239296,0.00003116086,0.0001368717,0.00003362769,0.0006302685,0.9903243,0.00008185495,0.001524948,0.000006596983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955187,0.002147629,0.001180808,0.00009418928,0.00005375266,0.00002172185,0.00020818,0.00006773746,0.0007072474],"genre_scores_gemma":[0.9965256,0.001139836,0.0006391642,0.00004725171,0.00001228365,0.0000356122,0.0002544229,0.00001263535,0.001333277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001473596,"threshold_uncertainty_score":0.004929721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008363208094075585,"score_gpt":0.2356293836081647,"score_spread":0.2272661755140891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}