{"id":"W3120003695","doi":"10.3389/fimmu.2020.577655","title":"CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis","year":2021,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"Biotechnology and Biological Sciences Research Council; National Institutes of Health; Versus Arthritis; Arthritis Research UK; National Institute for Health and Care Research; University College London; Wellcome Trust; Wellcome","keywords":"FOXP3; Treg cell; Homeostasis; CD80; Immunology; Biology; Medicine; Cell biology; Immune system; Genetics; T cell; IL-2 receptor; Cytotoxic T cell; CD40; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001982757,0.0004342125,0.0008786939,0.0004073917,0.0003688422,0.00002639049,0.0003108991,0.0009659142,0.0009735834],"category_scores_gemma":[0.00006581769,0.0003855093,0.0001089794,0.0003365751,0.00084214,0.0001160637,0.0002317856,0.0009108695,0.0001164366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001418395,"about_ca_system_score_gemma":0.00011946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007610031,"about_ca_topic_score_gemma":0.00008164924,"domain_scores_codex":[0.9970523,0.0006346744,0.0005119965,0.0008476965,0.00006183084,0.0008915631],"domain_scores_gemma":[0.9988158,0.0001489118,0.0002583998,0.0006471581,0.0000956072,0.00003415684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003964569,0.0005770194,0.007948283,0.00001163309,0.0005351502,0.000299388,0.0008662759,0.000001571463,0.9445868,0.0001520534,0.03859951,0.006025912],"study_design_scores_gemma":[0.005779535,0.0009919382,0.009111162,0.0001631519,0.00008524046,0.0001914691,0.001535847,0.000001590969,0.9307724,0.0006377342,0.05018806,0.0005418228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788162,0.01609429,0.0001074737,0.0005098202,0.00216415,0.0002653525,0.00006899034,0.0001157195,0.001858018],"genre_scores_gemma":[0.9866127,0.001189104,0.0003078291,0.0005394826,0.00001956823,0.00004764055,0.0004111558,0.00005306552,0.0108194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01490519,"threshold_uncertainty_score":0.9999397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009571089518015245,"score_gpt":0.2179969396632772,"score_spread":0.208425850145262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}