{"id":"W3120020820","doi":"10.1093/jnci/djaa216","title":"Neoadjuvant Immunotherapy for High-Risk, Resectable Malignancies: Scientific Rationale and Clinical Challenges","year":2020,"lang":"en","type":"review","venue":"JNCI Journal of the National Cancer Institute","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Medicine; Immunotherapy; Neoadjuvant therapy; Oncology; Melanoma; Adjuvant; Immune checkpoint; Immune system; Clinical trial; Cancer; Internal medicine; Immunology; Cancer research; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001959197,0.0008020419,0.001788315,0.001631306,0.0002591254,0.001464829,0.001100014,0.00180846,0.002187256],"category_scores_gemma":[0.001949619,0.0003457448,0.0007357036,0.001482271,0.0008728219,0.002293747,0.0006936669,0.003993003,0.001558389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007455816,"about_ca_system_score_gemma":0.001727726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000609064,"about_ca_topic_score_gemma":0.001248601,"domain_scores_codex":[0.9996585,0.00009931566,0.0000579501,0.000056124,0.0001052159,0.0000229073],"domain_scores_gemma":[0.9988431,0.0007419857,0.0001074323,0.00003355521,0.0002191387,0.00005487334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001286435,0.0001021514,0.0001226199,0.02049457,0.0001009618,0.0001311219,0.00005412067,0.0004151289,0.001533491,0.01001335,0.03136404,0.9355398],"study_design_scores_gemma":[0.00006938652,0.0002326267,0.0006425952,0.0122447,0.0001577108,0.0009192917,0.00006214413,0.0001827256,0.0005234017,0.005686201,0.9792519,0.00002726347],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005756324,0.9980938,0.0001353675,0.0009139037,0.0002413306,0.000008023353,0.00001177132,0.00000456308,0.0005337361],"genre_scores_gemma":[0.0004850221,0.9977768,0.0003153361,0.0007612255,0.0003050315,0.00001858868,0.00002109307,0.000002392749,0.0003144922],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002187256,"threshold_uncertainty_score":0.01036131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1890485329074185,"score_gpt":0.4288569071142234,"score_spread":0.2398083742068048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}