{"id":"W3120095939","doi":"10.2147/opth.s279364","title":"Phase 3 Efficacy (Worse-Eye Analysis) and Long-Term Safety Evaluation of OTX-101 in Patients with Keratoconjunctivitis Sicca","year":2021,"lang":"en","type":"article","venue":"Clinical ophthalmology","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Allergan; Valeant Pharmaceuticals International","keywords":"Medicine; Intraocular pressure; Ophthalmology; Adverse effect; KERATOCONJUNCTIVITIS SICCA; Visual acuity; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001033197,0.0001568705,0.0009087715,0.0001379921,0.00002780569,0.000006914783,0.00005564316,0.00022218,0.0007363189],"category_scores_gemma":[0.0007961838,0.0001297976,0.0001967101,0.0005687414,0.0001742424,0.00006520919,0.00005699613,0.0003009441,0.00001126322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003941014,"about_ca_system_score_gemma":0.0002621335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001405309,"about_ca_topic_score_gemma":0.00003680178,"domain_scores_codex":[0.9975434,0.0006588298,0.0007398381,0.000488827,0.0003495618,0.0002195267],"domain_scores_gemma":[0.9982388,0.0004626358,0.0002109624,0.0004597373,0.0004838145,0.0001440356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001870034,0.00416341,0.9726082,0.00002763025,0.0007937366,0.0004819879,0.00003630014,0.00001717773,0.00005916315,0.00001465263,0.000001599763,0.01992611],"study_design_scores_gemma":[0.02500954,0.00283516,0.9693315,0.00007397655,0.002130997,0.00002386783,0.00001501325,0.0002810434,0.0001462314,0.00001874144,0.00001309619,0.0001208384],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981684,0.0002538807,0.00006886346,0.0002465994,0.000118133,0.0005938155,0.00001463451,0.000008261701,0.0005273756],"genre_scores_gemma":[0.9992946,0.00002534968,0.0001539765,0.0001259824,0.00004341753,0.00001418794,0.0002240958,0.00001458923,0.0001037914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02313951,"threshold_uncertainty_score":0.8062176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04978017016616552,"score_gpt":0.410892087505646,"score_spread":0.3611119173394804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}