{"id":"W3120095939","doi":"10.2147/opth.s279364","title":"Phase 3 Efficacy (Worse-Eye Analysis) and Long-Term Safety Evaluation of OTX-101 in Patients with Keratoconjunctivitis Sicca","year":2021,"lang":"en","type":"article","venue":"Clinical ophthalmology","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Allergan; Valeant Pharmaceuticals International","keywords":"Medicine; Intraocular pressure; Ophthalmology; Adverse effect; KERATOCONJUNCTIVITIS SICCA; Visual acuity; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003010713,0.001149102,0.001833819,0.0004444649,0.0004905678,0.0008681407,0.0008576919,0.001079753,0.004627178],"category_scores_gemma":[0.001437966,0.000420461,0.002297513,0.0004226434,0.0007163535,0.0008043695,0.0003767636,0.002575857,0.0006479871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009179648,"about_ca_system_score_gemma":0.001875504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007113815,"about_ca_topic_score_gemma":0.001905029,"domain_scores_codex":[0.99913,0.0004260424,0.00005117032,0.00009745266,0.0001211359,0.0001742098],"domain_scores_gemma":[0.9982759,0.0003161049,0.0005429029,0.0001728169,0.000233211,0.0004590146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8039159,0.06536379,0.01049808,0.001225359,0.002073751,0.0002957036,0.0002913484,0.00181471,0.04233317,0.0002294695,0.003604251,0.06835447],"study_design_scores_gemma":[0.5109183,0.4564515,0.02460522,0.00005089273,0.0007630631,0.0003001922,0.0000496477,0.000837893,0.003754768,0.0001475764,0.002087756,0.00003329183],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920289,0.001489978,0.0006989888,0.0002191499,0.00007732177,0.002874141,0.001321336,0.00006401978,0.001226094],"genre_scores_gemma":[0.9870865,0.001131554,0.001916762,0.0006693502,0.0001810926,0.004514593,0.002769978,0.00002904687,0.001700993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004627178,"threshold_uncertainty_score":0.01592231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04978017016616552,"score_gpt":0.410892087505646,"score_spread":0.3611119173394804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}