{"id":"W3120099202","doi":"10.1136/gutjnl-2020-321534","title":"Genetic architectures of proximal and distal colorectal cancer are partly distinct","year":2021,"lang":"en","type":"review","venue":"Gut","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; School of Public Health, Imperial College London; Instituto de Salud Carlos III; World Cancer Research Fund; National Center for Advancing Translational Sciences; Medicinska fakulteten, Umeå Universitet; Medical Research Council; Canadian Cancer Society Research Institute; Centers for Disease Control and Prevention; Hellenic Health Foundation; Groupement des Entreprises Françaises dans la lutte contre le Cancer; National Institutes of Health; Centre Hospitalier Universitaire de Nantes; Institut Gustave-Roussy; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; Canadian Institutes of Health Research; Cancerfonden; Institut National de la Santé et de la Recherche Médicale; Imperial College London; Ontario Ministry of Research and Innovation; Cancer Research Foundation in Northern Sweden; Univerzita Karlova v Praze; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Bundesministerium für Bildung und Forschung; Association Anne de Bretagne Genetique; Division of Cancer Prevention, National Cancer Institute; National Institute for Health and Care Research; Stockholms Läns Landsting; Pelotonia; Västerbotten Läns Landsting; Mutuelle Générale de l'Education Nationale; Kempe Foundation; Johns Hopkins University; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; European Commission; Cancer Research UK; World Health Organization; Conseil Régional des Pays de la Loire; University of Cambridge; U.S. Department of Health and Human Services","keywords":"Genome-wide association study; Colorectal cancer; Genetic association; Carcinogenesis; Genetic heterogeneity; Biology; Genetics; Genetic architecture; Cancer; Bioinformatics; Medicine; Computational biology; Gene; Phenotype; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002412614,0.000563221,0.0007441271,0.001279065,0.0003423231,0.0009514531,0.0005402656,0.0006843553,0.00201543],"category_scores_gemma":[0.00527724,0.0003892527,0.001167813,0.001671858,0.001134679,0.0005252102,0.001091763,0.000540591,0.0002435229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002997704,"about_ca_system_score_gemma":0.0004053606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001773995,"about_ca_topic_score_gemma":0.002708343,"domain_scores_codex":[0.9974752,0.001019447,0.0002110539,0.0007351957,0.000378431,0.0001806163],"domain_scores_gemma":[0.9962593,0.001474867,0.00147624,0.0005012189,0.0001482116,0.0001401319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001853395,0.00004634099,0.9491976,0.0003936626,0.004313433,0.0007045174,0.0004114319,0.002431166,0.01852193,0.002295156,0.0002644002,0.01956695],"study_design_scores_gemma":[0.00006469768,0.0001483076,0.9885638,0.00007410568,0.001335436,0.001215686,0.0001271302,0.001572774,0.0009333215,0.00504578,0.0008960416,0.00002298967],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9858211,0.006204268,0.00586071,0.0004732667,0.0000126976,0.00002605776,0.0006012268,0.00006170462,0.0009389815],"genre_scores_gemma":[0.997851,0.0006293483,0.00108134,0.00006540109,0.00001376322,0.000009693834,0.000211543,0.00001211634,0.0001256771],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002412614,"threshold_uncertainty_score":0.01275927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215865483728276,"score_gpt":0.3180414176971359,"score_spread":0.2958827628598532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}