{"id":"W3120111865","doi":"10.1007/s15010-020-01554-w","title":"CRISPR-based strategies in infectious disease diagnosis and therapy","year":2021,"lang":"en","type":"review","venue":"Infection","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"William Osler Health System","funders":"Fundação para a Ciência e a Tecnologia; Centro de Investigação em Biomedicina","keywords":"CRISPR; Genome editing; Computational biology; Infectious disease (medical specialty); Cas9; Biology; Disease; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001145082,0.001486831,0.002049172,0.002480131,0.0002896208,0.001796541,0.001665458,0.001706687,0.004019537],"category_scores_gemma":[0.00104284,0.000429988,0.0005739084,0.002362258,0.0009952855,0.001398658,0.0009879675,0.003008452,0.003172114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001113876,"about_ca_system_score_gemma":0.001213829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001324026,"about_ca_topic_score_gemma":0.002597567,"domain_scores_codex":[0.9995794,0.00006290981,0.00003873877,0.00005700581,0.0002099952,0.00005203627],"domain_scores_gemma":[0.9995465,0.0002301399,0.00004927788,0.00001698094,0.0001019064,0.00005517756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009891742,0.00009357965,0.00006358632,0.01088397,0.0000685241,0.0001620392,0.00003237025,0.0006936011,0.005873286,0.007623223,0.06015974,0.9142472],"study_design_scores_gemma":[0.00002069663,0.00006323766,0.0002235939,0.001529283,0.00007335172,0.0005204928,0.00001913486,0.0001360347,0.001301681,0.002450658,0.9936402,0.00002153725],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006627136,0.9967411,0.0008346389,0.000310225,0.0004248369,0.000007529232,0.00003380107,0.00002982644,0.001551831],"genre_scores_gemma":[0.0005072468,0.9972227,0.0006405691,0.0002344496,0.000226257,0.000009870873,0.00006012785,0.000004631966,0.001094192],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004019537,"threshold_uncertainty_score":0.01344669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174400251424587,"score_gpt":0.365152051545919,"score_spread":0.3434080490316732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}