{"id":"W3120111865","doi":"10.1007/s15010-020-01554-w","title":"CRISPR-based strategies in infectious disease diagnosis and therapy","year":2021,"lang":"en","type":"review","venue":"Infection","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"William Osler Health System","funders":"Fundação para a Ciência e a Tecnologia; Centro de Investigação em Biomedicina","keywords":"CRISPR; Genome editing; Computational biology; Infectious disease (medical specialty); Cas9; Biology; Disease; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009899363,0.0002302604,0.0003598107,0.0001126883,0.00003202257,0.00006280648,0.00003753547,0.0002091932,0.00001501243],"category_scores_gemma":[0.00005835454,0.000219086,0.0001667479,0.0001478252,0.00002322807,0.000003318004,0.00003027342,0.0001357823,0.000002116985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002033118,"about_ca_system_score_gemma":0.0001798958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007910955,"about_ca_topic_score_gemma":0.0001158491,"domain_scores_codex":[0.999173,0.0001012242,0.0001993539,0.0003271807,0.00005625776,0.0001429196],"domain_scores_gemma":[0.9996124,0.00002818358,0.00005535473,0.0002127315,0.00002765555,0.00006368431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003837826,0.00007971084,0.00222594,0.001963688,0.00005160385,0.0000104512,0.000005480565,0.0005301847,0.00004084142,0.00001589246,0.0001372126,0.9949352],"study_design_scores_gemma":[0.0002182823,0.00008789458,0.0007652962,0.001190166,0.00007367467,0.000009492019,0.000002753692,0.00001843155,0.0002288544,0.00001434784,0.9971197,0.0002711373],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00286854,0.994,0.002461246,0.000005699727,0.000231509,0.0002984334,0.00001025008,0.00001975935,0.0001046087],"genre_scores_gemma":[0.01109798,0.988107,0.0000196085,0.00002268683,0.0001833112,0.0003260262,0.0001955577,0.00003296736,0.0000149172],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9969825,"threshold_uncertainty_score":0.8934069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174400251424587,"score_gpt":0.365152051545919,"score_spread":0.3434080490316732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}