{"id":"W3120128113","doi":"10.1093/mutage/geaa032","title":"<i>In vitro</i> mutagenicity of selected environmental carcinogens and their metabolites in MutaMouse FE1 lung epithelial cells","year":2020,"lang":"en","type":"article","venue":"Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"MRC-PHE Centre for Environment and Health; Cancer Research UK; Government of Canada","keywords":"Carcinogen; Chemistry; Metabolite; Genotoxicity; Benzo(a)pyrene; Mutagen; Biochemistry; Ames test; Cytochrome P450; In vitro; Metabolism; Molecular biology; Toxicity; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414195,0.0002483786,0.0003709568,0.00007304522,0.00003722911,0.00001358795,0.0001617798,0.0001464199,0.00003877204],"category_scores_gemma":[0.00002033617,0.0002386042,0.0001166266,0.0002212782,0.00008979089,0.000007071623,0.0001857891,0.0001001093,0.000002452387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003007124,"about_ca_system_score_gemma":0.00005463506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001852635,"about_ca_topic_score_gemma":0.00008982531,"domain_scores_codex":[0.9985722,0.0001305724,0.0003484636,0.0005010765,0.0001256508,0.0003220937],"domain_scores_gemma":[0.9995059,0.00002196073,0.00008980033,0.000237135,0.00001800418,0.000127214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002225132,0.0001218469,0.01389976,0.00004086423,0.0000534064,0.00001804166,0.0005757256,0.000152617,0.984287,0.000001669131,0.00005062704,0.0005759448],"study_design_scores_gemma":[0.0009178044,0.0001073933,0.03081511,0.000002746311,0.00003131689,0.00000687143,0.0002989838,0.0007697297,0.9658951,0.00000332712,0.0009199574,0.000231703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967278,0.001921071,0.0002196958,0.0001456756,0.00004506805,0.0003312426,0.0005755392,0.000007503549,0.00002635278],"genre_scores_gemma":[0.9985,0.0004419931,0.0003435393,0.000433123,0.00009929739,0.0000236037,0.00008877727,0.00003194274,0.00003771366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01839193,"threshold_uncertainty_score":0.9729995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005849886662235727,"score_gpt":0.1995458606838209,"score_spread":0.1936959740215852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}