{"id":"W3120128113","doi":"10.1093/mutage/geaa032","title":"<i>In vitro</i> mutagenicity of selected environmental carcinogens and their metabolites in MutaMouse FE1 lung epithelial cells","year":2020,"lang":"en","type":"article","venue":"Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"MRC-PHE Centre for Environment and Health; Cancer Research UK; Government of Canada","keywords":"Carcinogen; Chemistry; Metabolite; Genotoxicity; Benzo(a)pyrene; Mutagen; Biochemistry; Ames test; Cytochrome P450; In vitro; Metabolism; Molecular biology; Toxicity; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005544591,0.0005468699,0.0003583328,0.0003062702,0.0002440617,0.0002940729,0.0003081661,0.0004266487,0.001652968],"category_scores_gemma":[0.0002547755,0.0001695805,0.0005438189,0.000379485,0.0002313844,0.0002329579,0.0002927794,0.0004592816,0.0007008791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427165,"about_ca_system_score_gemma":0.0002076707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002429135,"about_ca_topic_score_gemma":0.003831852,"domain_scores_codex":[0.9991592,0.0003027402,0.0001311395,0.0001562345,0.0001656417,0.00008496736],"domain_scores_gemma":[0.9996922,0.00008622372,0.00005996387,0.00005923725,0.00008668246,0.0000157578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006200839,0.00004519874,0.0004831088,0.00005689742,0.000006525589,0.00004259365,0.00002469571,0.0000823744,0.998244,0.00003520048,0.00006364994,0.0008536796],"study_design_scores_gemma":[0.000002640919,0.000511341,0.003793817,0.00000489424,0.00001635748,0.000108465,0.00003322353,0.0003237167,0.9939623,0.00001464876,0.001224126,0.000004393474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769454,0.002386221,0.01270117,0.0002166675,0.0000676107,0.000200781,0.002848965,0.0002382033,0.004394994],"genre_scores_gemma":[0.968174,0.002516045,0.01556331,0.0002215329,0.00002750095,0.0003586386,0.006687886,0.00005713233,0.006394041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002429135,"threshold_uncertainty_score":0.005529702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005849886662235727,"score_gpt":0.1995458606838209,"score_spread":0.1936959740215852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}