{"id":"W3120128204","doi":"10.1186/s13063-020-04946-3","title":"The intranasal dexmedetomidine plus ketamine for procedural sedation in children, adaptive randomized controlled non-inferiority multicenter trial (Ketodex): a statistical analysis plan","year":2021,"lang":"en","type":"article","venue":"Trials","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; University of Toronto; Western University; London Health Sciences Centre; University of Manitoba; Children's Hospital Research Institute of Manitoba; Women and Children’s Health Research Institute; University of Alberta; Institute for Clinical Evaluative Sciences; SickKids Foundation; Hospital for Sick Children; Public Health Ontario","funders":"Alberta Children's Hospital Research Institute; Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba; Ontario Ministry of Economic Development, Job Creation and Trade; Hospital for Sick Children; Physicians' Services Incorporated Foundation; University of Alberta; Children's Health Foundation; Centre hospitalier universitaire Sainte-Justine; Western University; Kidscan Children's Cancer Research; Children's Health Research Institute; London Health Sciences Foundation; Academic Medical Organization of Southwestern Ontario; Women and Children's Health Research Institute; Ministero dello Sviluppo Economico","keywords":"Dexmedetomidine; Medicine; Ketamine; Sedation; Anesthesia; Randomized controlled trial; Nasal administration; Intensive care medicine; Pharmacology; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0669376,0.002565,0.005114091,0.001419056,0.0007167411,0.002181046,0.002028345,0.004169189,0.01005423],"category_scores_gemma":[0.06759662,0.001089213,0.006705588,0.001139791,0.002578106,0.002218427,0.001430516,0.004709581,0.0009896103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001887353,"about_ca_system_score_gemma":0.004438451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004756006,"about_ca_topic_score_gemma":0.0006831315,"domain_scores_codex":[0.9283239,0.06311044,0.002266536,0.002494654,0.002545604,0.00125877],"domain_scores_gemma":[0.974744,0.01643073,0.004371235,0.002070578,0.001508955,0.0008744558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8923463,0.003151306,0.003620372,0.008835605,0.009897173,0.0002156001,0.0003995444,0.008618237,0.002512067,0.01664072,0.007239345,0.04652365],"study_design_scores_gemma":[0.8769444,0.04874833,0.003476028,0.001467709,0.006715453,0.0001497733,0.0001072015,0.03657224,0.001615548,0.01326026,0.01079967,0.000143382],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1362759,0.006063876,0.1138297,0.007754162,0.003375094,0.7192144,0.004724878,0.001492243,0.007269711],"genre_scores_gemma":[0.1431857,0.0009624021,0.1482433,0.002933857,0.0004728878,0.7010729,0.0008954769,0.00007336971,0.002160013],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0669376,"threshold_uncertainty_score":0.3540041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06066438302373969,"score_gpt":0.3719355809983068,"score_spread":0.3112711979745671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}