{"id":"W3120166422","doi":"10.1016/j.celrep.2020.108586","title":"A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Nuclear export signal; Cytoplasm; Cytosol; Biology; Cell biology; Nuclear localization sequence; Nuclear transport; DNA; Subcellular localization; Nucleus; Cell nucleus; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00022316,0.0001809331,0.0003124994,0.00007735191,0.0001658793,0.00002696438,0.0000720264,0.0002139948,0.002848017],"category_scores_gemma":[0.0001069292,0.000176596,0.0002137603,0.0001032309,0.00006450042,0.00005232734,0.0001154405,0.0001344166,0.0004872609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000410628,"about_ca_system_score_gemma":0.0001870221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007807404,"about_ca_topic_score_gemma":0.000002019435,"domain_scores_codex":[0.9985313,0.00008872514,0.0004660707,0.0004561336,0.00003881737,0.000418968],"domain_scores_gemma":[0.9990048,0.00007851966,0.0001504085,0.0005441417,0.0001738281,0.0000483103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003462759,0.0001085786,0.00005933043,0.00002052722,0.00006733124,0.0009996294,0.0008183229,4.265035e-7,0.9239872,0.0001069935,0.07277545,0.0007099926],"study_design_scores_gemma":[0.0002461104,0.0001711358,0.0001569133,0.00001377488,0.00002212408,0.002064855,0.0002384626,6.324795e-7,0.5775976,0.00004791303,0.4193131,0.0001273655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867677,0.0007862821,0.0001532669,0.0007699203,0.001056842,0.0003092405,0.00001551505,0.00008998093,0.01005126],"genre_scores_gemma":[0.9202255,0.000015576,0.0001863533,0.001694513,0.00004200245,0.00002846739,0.00006754586,0.00003741736,0.0777026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3465376,"threshold_uncertainty_score":0.9980635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01738596704868313,"score_gpt":0.2488648389799623,"score_spread":0.2314788719312791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}