{"id":"W3120238974","doi":"10.1158/0008-5472.can-20-2222","title":"Multiomics Characterization of Low-Grade Serous Ovarian Carcinoma Identifies Potential Biomarkers of MEK Inhibitor Sensitivity and Therapeutic Vulnerability","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; BC Cancer Agency; Ovarian Cancer Canada; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Canada Foundation for Innovation","keywords":"KRAS; CDKN2A; Selumetinib; Cancer research; Neuroblastoma RAS viral oncogene homolog; Targeted therapy; MEK inhibitor; Medicine; Synthetic lethality; Cancer; Biology; Mutation; Gene; Internal medicine; Kinase; Genetics; DNA repair; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445583,0.0002422543,0.0002101003,0.0008684774,0.0001312455,0.0004052945,0.0001018261,0.0001887057,0.0005477839],"category_scores_gemma":[0.0002156957,0.0001016092,0.0002026541,0.0004171581,0.0001238713,0.0001497887,0.0002247142,0.0001878639,0.000170551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001373203,"about_ca_system_score_gemma":0.0001014276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005818068,"about_ca_topic_score_gemma":0.0007914686,"domain_scores_codex":[0.9999284,0.000008389759,0.000006598651,0.00001848101,0.00002448808,0.00001374164],"domain_scores_gemma":[0.9998798,0.00002370836,0.0000398976,0.0000142855,0.00002603029,0.0000162668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001680816,0.00001926346,0.0291866,0.00005523545,0.00003510346,0.0001245654,0.00003599605,0.0002005285,0.9655439,0.00003401416,0.00006271538,0.004533933],"study_design_scores_gemma":[0.00001409531,0.0003370544,0.4884391,0.00001575611,0.000126771,0.00170711,0.0002268781,0.006647074,0.4996884,0.0002114669,0.002567356,0.00001902418],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952904,0.0006581934,0.002343716,0.00003196243,0.000004836972,0.00001861714,0.001183919,0.0000488208,0.0004194936],"genre_scores_gemma":[0.9954555,0.0003668834,0.002416307,0.00003243355,0.000003533833,0.00002028467,0.001314647,0.00001383548,0.0003765091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008684774,"threshold_uncertainty_score":0.001832545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05249500699688612,"score_gpt":0.3601726168115972,"score_spread":0.3076776098147111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}