{"id":"W3120241209","doi":"10.1016/s1470-2045(20)30642-2","title":"Palbociclib with adjuvant endocrine therapy in early breast cancer (PALLAS): interim analysis of a multicentre, open-label, randomised, phase 3 study","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":255,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Pfizer","keywords":"Palbociclib; Interim analysis; Medicine; Interim; Adjuvant; Oncology; Breast cancer; Internal medicine; Cancer; Endocrine system; Adjuvant therapy; Gynecology; Clinical trial; Metastatic breast cancer; History; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005144823,0.0002679033,0.002004261,0.0001886004,0.00005438863,0.00002257424,0.0004533727,0.00005856576,0.0007633908],"category_scores_gemma":[0.00004625019,0.0001610139,0.00008946756,0.001340694,0.000217359,0.0001145542,0.0001839986,0.0003667798,0.000004039081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002780326,"about_ca_system_score_gemma":0.0004498715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001993514,"about_ca_topic_score_gemma":0.009135486,"domain_scores_codex":[0.9976203,0.0005930369,0.0005600698,0.0004727787,0.0002703981,0.000483405],"domain_scores_gemma":[0.9980815,0.0003824829,0.0003427133,0.0007828522,0.0003087317,0.0001017164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3642294,0.01466992,0.3432846,0.00006347106,0.01149025,0.001476373,0.01341592,0.0003526935,0.02206589,0.00006431926,0.00008166007,0.2288054],"study_design_scores_gemma":[0.6183466,0.00550858,0.3610713,0.000180173,0.002492138,0.0002421851,0.004477841,0.0007064948,0.002235468,0.00003700159,0.004391242,0.0003110356],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899983,0.0020011,0.00009647845,0.005373264,0.000112545,0.001824767,0.0001220507,0.00003277621,0.0004387046],"genre_scores_gemma":[0.995307,0.001142023,0.0007379276,0.001732468,0.0001895224,0.0005554744,0.00002740439,0.00003758196,0.0002705535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2541171,"threshold_uncertainty_score":0.8358594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08323415090640111,"score_gpt":0.4366332390939129,"score_spread":0.3533990881875118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}