{"id":"W3120252752","doi":"10.3324/haematol.2020.269944","title":"Reversible switching of leukemic cells to a drug-resistant, stem-like subset via IL-4-mediated cross-talk with mesenchymal stroma","year":2021,"lang":"en","type":"article","venue":"Haematologica","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"College of Medicine, Catholic University of Korea; Seoul National University","keywords":"Mesenchymal stem cell; Stroma; Stromal cell; Cancer research; Biology; Cell biology; Progenitor cell; Cell; Stem cell; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003057432,0.000305337,0.0008894802,0.0001576815,0.0001113108,0.00003408313,0.00018243,0.0001793821,0.0004606928],"category_scores_gemma":[0.00005653772,0.000241287,0.0001389439,0.0006946568,0.00008308548,0.00010269,0.00005716539,0.0002624883,0.0001304625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009633071,"about_ca_system_score_gemma":0.0003252015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001189286,"about_ca_topic_score_gemma":0.0001283403,"domain_scores_codex":[0.9974917,0.0001357038,0.0006758481,0.0005906346,0.0006098472,0.0004962301],"domain_scores_gemma":[0.998204,0.0003542027,0.0002365189,0.0005874736,0.0003164799,0.0003013169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001310174,0.0002609816,0.02684319,0.001817369,0.0001830661,0.005790158,0.001637094,0.00005634022,0.960858,0.0001832686,0.0009690781,0.00009125702],"study_design_scores_gemma":[0.003791681,0.000659688,0.02461748,0.001423001,0.0003304274,0.003589708,0.002069261,0.0002176206,0.9616255,0.00005576121,0.001147864,0.000472053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993569,0.0001973555,0.002540336,0.0003682954,0.0001546844,0.0006300531,0.00008273793,0.0001315343,0.002326068],"genre_scores_gemma":[0.991477,0.00003847623,0.006811823,0.0003136256,0.00002322313,0.00003389451,0.00009615128,0.00003924546,0.001166526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004271486,"threshold_uncertainty_score":0.9839398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705753678729018,"score_gpt":0.2582867410981921,"score_spread":0.2412292043109019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}