{"id":"W3120314388","doi":"10.21203/rs.3.rs-135545/v1","title":"Purinergic Signaling Participates in a Transition Between Functional States of Reactive Microglia and Controls Astrocyte-Driven Neuroinflammation in the Model of Trimethyltin-Induced Neurodegeneration","year":2020,"lang":"en","type":"preprint","venue":"","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculté de Médecine, Université Laval; Université Laval","keywords":"Neuroinflammation; Neurodegeneration; Microglia; Astrocyte; Neuroscience; Purinergic receptor; Chemistry; Medicine; Biology; Immunology; Cell biology; Central nervous system; Inflammation; Disease; Pathology; Extracellular","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439345,0.0004179255,0.0003077395,0.0003178038,0.0001997712,0.0003406305,0.0001935988,0.0003477084,0.001452014],"category_scores_gemma":[0.00008045366,0.0001644772,0.0002822057,0.0001406396,0.000263073,0.0003363312,0.0001845866,0.0006392743,0.0003255643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002430379,"about_ca_system_score_gemma":0.0001651741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003132797,"about_ca_topic_score_gemma":0.0006022138,"domain_scores_codex":[0.9998661,0.00001605794,0.00001374119,0.00002552666,0.00003039617,0.00004812357],"domain_scores_gemma":[0.9999146,0.000004247543,0.00003635014,0.000007345896,0.00001040088,0.0000270139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008567203,0.00006761144,0.0006051096,0.00006414944,0.000007422941,0.0003073098,0.00004407615,0.00002445655,0.9966267,0.00007069574,0.00004458839,0.001281306],"study_design_scores_gemma":[0.00006995053,0.001404673,0.04268658,0.00003136022,0.00006740164,0.001449725,0.0003027902,0.0008743738,0.9504867,0.0002454499,0.002366078,0.00001492565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960239,0.001491014,0.001219848,0.0000847628,0.00002955257,0.00003760164,0.0002043766,0.00004238202,0.0008664711],"genre_scores_gemma":[0.9938306,0.001519276,0.001433342,0.00006793351,0.00003026488,0.0001227357,0.0003116533,0.00001299507,0.002671268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001452014,"threshold_uncertainty_score":0.004857421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.053479039769572,"score_gpt":0.2687784244151042,"score_spread":0.2152993846455322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}