{"id":"W3120325003","doi":"10.1038/s41594-020-00535-9","title":"Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation","year":2021,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Université de Sherbrooke","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; Howard Hughes Medical Institute","keywords":"PRC2; RNA; RNA polymerase II; Biology; Transcription (linguistics); Cell biology; Chromatin; Molecular biology; Genetics; Gene expression; Gene; Promoter; Histone H3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005504991,0.0002055999,0.0001973039,0.00005879494,0.0001491395,0.00004441993,0.0001322727,0.0004651676,0.00003644908],"category_scores_gemma":[0.00005851229,0.0001896226,0.000110821,0.0001289662,0.0001160418,0.0000133127,0.00006380212,0.0003608971,0.000001956275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002778265,"about_ca_system_score_gemma":0.00005237056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001154314,"about_ca_topic_score_gemma":0.00005819869,"domain_scores_codex":[0.9987752,0.0001540629,0.0001944105,0.0005474523,0.0000912895,0.0002375378],"domain_scores_gemma":[0.9992118,0.000008947938,0.0001338447,0.0003503639,0.0002092783,0.00008569949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002628644,0.000005690842,0.004590828,0.00001109824,0.0001020231,0.000006455122,0.00003485246,0.00003290674,0.9853591,0.001405101,0.0001944021,0.008231263],"study_design_scores_gemma":[0.0005635896,0.00009388312,0.1365933,0.00002286969,0.00006228506,0.00009442888,0.0000953311,0.0001036386,0.8447818,0.002420122,0.0148577,0.0003110627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987341,0.003616923,0.006257627,0.001904898,0.0003965723,0.0001739548,0.0001252759,0.00002275735,0.0001609473],"genre_scores_gemma":[0.995702,0.0002900817,0.001417141,0.0004908523,0.0002140735,0.00001858761,0.00157525,0.00002435163,0.0002677196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1405773,"threshold_uncertainty_score":0.7732586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102724754836665,"score_gpt":0.3054055134596813,"score_spread":0.2951330379760148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}