{"id":"W3120343547","doi":"10.3389/fphar.2020.572637","title":"Kanglexin protects against cardiac fibrosis and dysfunction in mice by TGF-β1/ERK1/2 noncanonical pathway","year":2021,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Heilongjiang Provincial Postdoctoral Science Foundation; National Major Science and Technology Projects of China; Natural Science Foundation of Heilongjiang Province; National Natural Science Foundation of China; Fonds de Recherche du Québec - Santé; Harbin Medical University","keywords":"Cardiac fibrosis; Fibrosis; Umbilical vein; Myofibroblast; Medicine; Bleomycin; Pharmacology; Doxorubicin; Internal medicine; Endocrinology; Chemistry; Chemotherapy; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003630865,0.0002070986,0.0006705219,0.0001965615,0.00005598203,0.00001751616,0.00005713343,0.0002986273,0.00003622937],"category_scores_gemma":[0.00006187105,0.0002072916,0.0001452491,0.0004057768,0.0001080527,0.00008640205,0.00009083189,0.0005723005,0.000005172528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003168272,"about_ca_system_score_gemma":0.0002766931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005265326,"about_ca_topic_score_gemma":0.00000949474,"domain_scores_codex":[0.9981841,0.0002625149,0.000386602,0.0005431297,0.0001801671,0.0004434714],"domain_scores_gemma":[0.9994988,0.00006202172,0.00006811696,0.000137943,0.00007029132,0.0001628022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005461472,0.0001984648,0.02369381,0.0001612653,0.0001295083,0.000112372,0.0002921005,0.000173825,0.8683749,0.000004813951,0.08251596,0.02379683],"study_design_scores_gemma":[0.01818793,0.0006507584,0.03488833,0.000556018,0.0004011339,0.0001107365,0.001596184,0.01907798,0.6658893,0.0001323617,0.257475,0.001034363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769449,0.0148027,0.0006611798,0.001468645,0.003467819,0.0007833067,0.00005052296,0.00004469262,0.0017762],"genre_scores_gemma":[0.9895837,0.002441761,0.005052073,0.001473057,0.0004409649,0.000153923,0.0001232477,0.00004581702,0.0006854011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2024857,"threshold_uncertainty_score":0.8453104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008232114357915208,"score_gpt":0.2520419636875951,"score_spread":0.2438098493296799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}