{"id":"W3120349484","doi":"10.1021/acs.langmuir.0c02796","title":"Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications: A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin)","year":2021,"lang":"en","type":"article","venue":"Langmuir","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McMaster University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Contact lens; Self-healing hydrogels; Hyaluronic acid; Silicone hydrogel; Biofouling; Contact angle; Wetting; Materials science; Chemical engineering; Lubricant; Lens (geology); Chemistry; Nanotechnology; Biomedical engineering; Polymer chemistry; Composite material; Ophthalmology; Optics; Membrane; Biochemistry; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001835235,0.0001511445,0.0004494309,0.00003057208,0.0001806231,0.00003296968,0.00008758812,0.00003560123,0.000005875379],"category_scores_gemma":[0.0001495272,0.0001089904,0.00006428631,0.0002012659,0.0001004049,0.00007926596,0.00009066425,0.0002212841,0.000001400515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003488312,"about_ca_system_score_gemma":0.00009680653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002406462,"about_ca_topic_score_gemma":0.0003370726,"domain_scores_codex":[0.9989802,0.0001223385,0.000279921,0.0002828625,0.0001578639,0.0001768525],"domain_scores_gemma":[0.9988675,0.0003751905,0.0001476299,0.0003558806,0.0001919588,0.0000618439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002303032,0.0006663338,0.6593422,0.0006515818,0.001894768,0.00003591146,0.01315715,0.0000108618,0.3178281,0.002698989,0.0002025138,0.003281279],"study_design_scores_gemma":[0.01103159,0.001567837,0.8663158,0.0005142869,0.002147891,0.00007825517,0.04139526,0.002019692,0.06765437,0.0007746718,0.005909376,0.0005909886],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938956,0.002440785,0.0003418881,0.0009613411,0.0000274345,0.002127616,0.00006355322,0.00002852581,0.0001131982],"genre_scores_gemma":[0.9984497,0.00001494047,0.0009481798,0.0001132166,0.00004986665,0.0002052083,0.00004914087,0.00001622457,0.0001534767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2501738,"threshold_uncertainty_score":0.4444499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04037812141836079,"score_gpt":0.3212737812434858,"score_spread":0.280895659825125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}