{"id":"W3120349484","doi":"10.1021/acs.langmuir.0c02796","title":"Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications: A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin)","year":2021,"lang":"en","type":"article","venue":"Langmuir","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McMaster University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Contact lens; Self-healing hydrogels; Hyaluronic acid; Silicone hydrogel; Biofouling; Contact angle; Wetting; Materials science; Chemical engineering; Lubricant; Lens (geology); Chemistry; Nanotechnology; Biomedical engineering; Polymer chemistry; Composite material; Ophthalmology; Optics; Membrane; Biochemistry; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002058603,0.0003396058,0.0002617986,0.0001652688,0.0001126293,0.0002246855,0.0001558729,0.0002297153,0.0005874733],"category_scores_gemma":[0.0002309553,0.0001172856,0.0003226508,0.00015521,0.0001364495,0.0002886912,0.0002190348,0.0001594352,0.000112582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001500637,"about_ca_system_score_gemma":0.000119746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000378099,"about_ca_topic_score_gemma":0.0006158677,"domain_scores_codex":[0.9998059,0.00004015635,0.00001202286,0.00003168435,0.00007021656,0.00004011807],"domain_scores_gemma":[0.9998803,0.00003846076,0.00003147763,0.000007049081,0.00002703674,0.00001562068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006171504,0.00001841347,0.00008642629,0.00007234332,0.000009456665,0.00002215037,0.00001340585,0.00004328716,0.998516,0.00001397033,0.000006926249,0.001135989],"study_design_scores_gemma":[0.000005976591,0.0006492789,0.001444199,0.000003776207,0.00003647191,0.0000943124,0.00002789712,0.000535519,0.9962621,0.000008757064,0.0009259935,0.000005780917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962854,0.002493228,0.0008141852,0.00001474018,0.00001143303,0.00001164104,0.00002359996,0.000005789935,0.0003398611],"genre_scores_gemma":[0.9959441,0.001520561,0.001777903,0.00001970272,0.000008540262,0.00001535404,0.00004177416,0.00000616434,0.000665791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005874733,"threshold_uncertainty_score":0.001965284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04037812141836079,"score_gpt":0.3212737812434858,"score_spread":0.280895659825125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}