{"id":"W3120365639","doi":"10.1002/stem.3325","title":"<i>NRL</i> −/− gene edited human embryonic stem cells generate rod-deficient retinal organoids enriched in S-cone-like photoreceptors","year":2021,"lang":"en","type":"article","venue":"Stem Cells","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Great Ormond Street Hospital Biomedical Research Centre; Medical Research Council; Medical Research Council Canada; Great Ormond Street Hospital Charity; Wellcome Trust; Saudi Arabia Cultural Bureau in London; Academy of Medical Sciences; Fight for Sight UK; National Institute for Health and Care Research","keywords":"Biology; Organoid; Embryonic stem cell; Cell biology; Retina; Retinal; Stem cell; Muller glia; Genetics; Gene; Neuroscience; Progenitor cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003427994,0.0004082589,0.0003719793,0.0001101171,0.0001580846,0.00009075467,0.0003400181,0.0003181592,0.0002153332],"category_scores_gemma":[0.000004404137,0.000420034,0.0001709919,0.0004710437,0.00009030451,0.000008715554,0.0002576054,0.000217093,0.0001373266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000079826,"about_ca_system_score_gemma":0.0002973341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002317588,"about_ca_topic_score_gemma":0.00007844558,"domain_scores_codex":[0.9973196,0.0002045761,0.0005425282,0.0009173181,0.0003510863,0.0006649414],"domain_scores_gemma":[0.9988722,0.00001633381,0.0001811602,0.0005577362,0.0001963581,0.0001762204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006511387,0.0001505314,0.001872765,0.00005634551,0.00004428067,0.00005240697,0.0001826416,0.0001361081,0.9861888,0.00001622867,0.01089567,0.0003391665],"study_design_scores_gemma":[0.001128176,0.0001556891,0.0004699884,0.00002760312,0.00002251883,0.00001070191,0.0005278527,0.00003209218,0.9512861,0.000007716691,0.04580981,0.0005217766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939662,0.001868961,0.0001381522,0.00007800314,0.001267021,0.0003271961,0.00002752772,0.00003338314,0.00229354],"genre_scores_gemma":[0.9804563,0.0005981588,0.0003344444,0.0004985753,0.0003005277,0.00004180124,0.0003441292,0.0000751382,0.01735095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03491415,"threshold_uncertainty_score":0.9998251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008720332034705573,"score_gpt":0.2155934971817916,"score_spread":0.2068731651470861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}