{"id":"W3120365639","doi":"10.1002/stem.3325","title":"<i>NRL</i> −/− gene edited human embryonic stem cells generate rod-deficient retinal organoids enriched in S-cone-like photoreceptors","year":2021,"lang":"en","type":"article","venue":"Stem Cells","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Great Ormond Street Hospital Biomedical Research Centre; Medical Research Council; Medical Research Council Canada; Great Ormond Street Hospital Charity; Wellcome Trust; Saudi Arabia Cultural Bureau in London; Academy of Medical Sciences; Fight for Sight UK; National Institute for Health and Care Research","keywords":"Biology; Organoid; Embryonic stem cell; Cell biology; Retina; Retinal; Stem cell; Muller glia; Genetics; Gene; Neuroscience; Progenitor cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001938894,0.0003684373,0.0002571383,0.0002595598,0.000131432,0.000335918,0.0002841419,0.0002444623,0.001987593],"category_scores_gemma":[0.0001022808,0.0002107827,0.0002715926,0.0001232065,0.0002518393,0.0001232039,0.0002376328,0.0004695504,0.0009943121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002172331,"about_ca_system_score_gemma":0.0001663959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000753127,"about_ca_topic_score_gemma":0.0008877059,"domain_scores_codex":[0.9998379,0.0000143,0.00003128279,0.00004491295,0.00005105113,0.00002068885],"domain_scores_gemma":[0.9998046,0.00003207694,0.00006937473,0.00003681844,0.00001992056,0.00003732363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001698215,0.000006483126,0.00008185171,0.00001241664,0.000002418181,0.00003648555,0.00001138422,0.00003969181,0.9992825,0.00008648406,0.00003048842,0.0003927837],"study_design_scores_gemma":[0.000007470278,0.00005395364,0.001357658,0.000004752352,0.000008092185,0.0001492044,0.00001964591,0.0007791246,0.9949816,0.00002909528,0.002606185,0.000003349503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707553,0.000678285,0.01998851,0.0001084061,0.0001016293,0.000133005,0.002713161,0.0006778446,0.004843986],"genre_scores_gemma":[0.973151,0.0004520445,0.01181799,0.00008226839,0.00001272213,0.00009525535,0.002494648,0.0002839404,0.01161011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001987593,"threshold_uncertainty_score":0.006649196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008720332034705573,"score_gpt":0.2155934971817916,"score_spread":0.2068731651470861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}