{"id":"W3120439041","doi":"10.1111/nan.12694","title":"Molecular pathophysiology of human MICU1 deficiency","year":2021,"lang":"en","type":"article","venue":"Neuropathology and Applied Neurobiology","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Leibniz-Gemeinschaft; European Research Council; Medical Research Council; Canadian Institutes of Health Research; Newton Fund; Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen; National Institute of General Medical Sciences; Bundesministerium für Bildung und Forschung; National Institutes of Health; Canada Research Chairs; Ataxia UK; Muscular Dystrophy Canada; Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen; Wellcome Trust; French Muscular Dystrophy Association; European Regional Development Fund; European Commission; Center for Scientific Review; Muscular Dystrophy Association","keywords":"Biology; Spectrin; Cell biology; Mitochondrion; Pathophysiology; Neuroscience; Cytoskeleton; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008795571,0.0001783329,0.0004731725,0.00009937806,0.00007925881,0.000002183879,0.00007371108,0.0003087831,0.00004318084],"category_scores_gemma":[0.00004906238,0.0001504776,0.00008775561,0.0001951998,0.0006090539,0.000008545583,0.0001308408,0.0003515776,0.00001482771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003583813,"about_ca_system_score_gemma":0.00004462698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.659651e-7,"about_ca_topic_score_gemma":3.34779e-7,"domain_scores_codex":[0.9986035,0.0002014359,0.0003149835,0.0005350562,0.00004593507,0.0002991514],"domain_scores_gemma":[0.9993642,0.00007602163,0.0001051008,0.0003121753,0.00006010957,0.00008241615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001141119,0.0001640088,0.002206705,0.00005458714,0.00001460886,0.00103077,0.00003538497,0.000003891088,0.9873226,0.007998773,0.00004457395,0.001009983],"study_design_scores_gemma":[0.002065895,0.00144665,0.144178,0.00001593714,0.0001836949,0.004063941,0.00005667506,0.000006603885,0.8449377,0.002391454,0.0004313062,0.0002221543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901536,0.0004790488,0.00002253338,0.0004063654,0.0001698321,0.0001479407,0.000006105481,0.00004397269,0.008570645],"genre_scores_gemma":[0.996551,0.0002190336,0.0001605433,0.00288599,0.00002517045,0.00000886725,0.00004238352,0.00002036957,0.00008668676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1423849,"threshold_uncertainty_score":0.61363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00743188390453855,"score_gpt":0.234503075100978,"score_spread":0.2270711911964395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}