{"id":"W3120464099","doi":"10.1016/j.immuni.2020.12.012","title":"Spliceosome-Targeted Therapies Induce dsRNA Responses","year":2021,"lang":"en","type":"letter","venue":"Immunity","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Biology; Spliceosome; Computational biology; Virology; RNA; Cancer research; Genetics; RNA splicing; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002216936,0.0007449345,0.000788793,0.0004841265,0.001607197,0.002314332,0.0007422567,0.01930443,0.004441166],"category_scores_gemma":[0.005788218,0.000382727,0.0008288113,0.0002344913,0.00218333,0.001226992,0.0007050329,0.01360625,0.002484568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00301868,"about_ca_system_score_gemma":0.0008095083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009429964,"about_ca_topic_score_gemma":0.002229453,"domain_scores_codex":[0.9988493,0.0003333917,0.00008505172,0.0001186117,0.0004413732,0.0001722417],"domain_scores_gemma":[0.9978324,0.001683518,0.0001081471,0.00007436292,0.0001727042,0.0001288648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006752629,0.0002073339,0.0005994212,0.0001918507,0.0000519504,0.004534633,0.0001065803,0.0003275255,0.007336028,0.03015641,0.9049165,0.05089651],"study_design_scores_gemma":[0.0005903517,0.0002706711,0.0009958871,0.0001139033,0.00004463422,0.003312871,0.0001152744,0.001811559,0.01025671,0.0343391,0.9480984,0.00005062401],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.003826006,0.01213653,0.00309704,0.8953814,0.05535316,0.0001441762,0.0001602535,0.0002068895,0.02969453],"genre_scores_gemma":[0.05317425,0.0100545,0.002769784,0.8092748,0.05944708,0.0004082409,0.000119108,0.0001106674,0.06464168],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01930443,"threshold_uncertainty_score":0.02190214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862956159402361,"score_gpt":0.2699211904502917,"score_spread":0.2412916288562681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}