{"id":"W3120511704","doi":"10.3389/fgeed.2020.606281","title":"CRISPR-Based Genetic Manipulation of Candida Species: Historical Perspectives and Current Approaches","year":2021,"lang":"en","type":"review","venue":"Frontiers in Genome Editing","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Genome editing; Biology; Cas9; Computational biology; Antifungal drug; Genome; Model organism; Genetics; Candida albicans; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001687245,0.0009401364,0.001039361,0.002016328,0.0005462767,0.002325893,0.001051571,0.001349909,0.001311917],"category_scores_gemma":[0.001362002,0.0005296625,0.0005835493,0.002025708,0.001513628,0.0020717,0.001042322,0.003181177,0.0007804791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001051788,"about_ca_system_score_gemma":0.001354888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001383973,"about_ca_topic_score_gemma":0.001478832,"domain_scores_codex":[0.9994129,0.00009543632,0.0000847159,0.0001704254,0.0001806824,0.00005575853],"domain_scores_gemma":[0.9991936,0.0004287616,0.00007968225,0.00003815634,0.0001668881,0.000092875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001437105,0.00009605709,0.0008258814,0.0175514,0.0001230348,0.0006089777,0.0005966372,0.001283984,0.01801596,0.03773298,0.0169369,0.9060846],"study_design_scores_gemma":[0.00001279243,0.0002051826,0.001303231,0.002959704,0.0001335076,0.001839437,0.0002457729,0.0004035012,0.006830811,0.009609947,0.9763639,0.00009215085],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007418714,0.9924972,0.002194257,0.001024072,0.0003627116,0.00001001905,0.00003511786,0.00003357082,0.003101176],"genre_scores_gemma":[0.004911096,0.9911563,0.002098584,0.0006340405,0.0003607443,0.00001925141,0.00006802404,0.0000102696,0.0007416012],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002325893,"threshold_uncertainty_score":0.008923113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1086250853034188,"score_gpt":0.3198359863790741,"score_spread":0.2112109010756553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}