{"id":"W3120529577","doi":"10.1016/j.bbamem.2021.183558","title":"On the relationship between anion binding and chloride conductance in the CFTR anion channel","year":2021,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chloride channel; Conductance; Ion; Chloride; Chemistry; Channel (broadcasting); Biophysics; Computer science; Biochemistry; Mathematics; Biology; Computer network; Organic chemistry; Combinatorics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000864089,0.0002970432,0.0005821996,0.0007720499,0.0005005379,0.001027083,0.0007772619,0.0008830379,0.002994903],"category_scores_gemma":[0.001846909,0.0002687751,0.0003879834,0.0005106314,0.001166265,0.002352813,0.00054657,0.001371458,0.0006995268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004840094,"about_ca_system_score_gemma":0.0002484972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356603,"about_ca_topic_score_gemma":0.0009975315,"domain_scores_codex":[0.9996988,0.0001067104,0.00002967054,0.00006456201,0.00006301473,0.00003728799],"domain_scores_gemma":[0.9981766,0.00157052,0.00006328274,0.00004846903,0.00008984259,0.00005132951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007126796,0.0003364643,0.004387927,0.001243395,0.0001366727,0.003992705,0.0006119925,0.006779746,0.827518,0.08238588,0.002537225,0.06294321],"study_design_scores_gemma":[0.0002879353,0.002328751,0.05431541,0.0002947567,0.0003971469,0.004574768,0.000894236,0.05305672,0.7635052,0.0788202,0.04124671,0.0002782367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8584976,0.07333374,0.03166325,0.01038286,0.001011763,0.00007519993,0.0005629501,0.000256333,0.0242163],"genre_scores_gemma":[0.9633203,0.02628024,0.00272381,0.001310934,0.0006915258,0.00002882366,0.0002829558,0.00007216461,0.005289298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002994903,"threshold_uncertainty_score":0.01001894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04765690743132419,"score_gpt":0.2797517018616583,"score_spread":0.2320947944303341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}