{"id":"W3120564033","doi":"10.1016/j.cell.2020.11.018","title":"Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":497,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vector Institute; Ontario Institute for Cancer Research; University Health Network; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Cancer; Colorectal cancer; Chemotherapy; Diapause; Cancer research; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006775492,0.0001550684,0.000273413,0.00004260868,0.00003909947,0.0000160439,0.00007011244,0.00006139788,0.001620147],"category_scores_gemma":[0.000001773187,0.000131017,0.0001048248,0.0001926062,0.00002454187,0.00002593455,0.00001481743,0.0001271748,0.0001973364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006459364,"about_ca_system_score_gemma":0.0001604646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008874825,"about_ca_topic_score_gemma":0.0005507958,"domain_scores_codex":[0.9989858,0.00001786383,0.0001664551,0.0003091495,0.0002103678,0.0003103429],"domain_scores_gemma":[0.9994223,0.00001779379,0.00003305496,0.0001996853,0.0001092392,0.0002179329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002972123,0.0002058898,0.001372896,0.0001003735,0.00005078769,0.0003272567,0.00159992,0.00001465668,0.9901348,0.000005242676,0.005029236,0.0008616985],"study_design_scores_gemma":[0.001331191,0.00009405893,0.006369371,0.00006634872,0.00004095248,0.000003432939,0.0001808311,0.00001229737,0.9103919,0.0000221096,0.08133663,0.00015087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921805,0.0004014983,0.000610011,0.0009155515,0.0009936232,0.0003085426,0.00005536369,0.00005742954,0.004477539],"genre_scores_gemma":[0.9494374,0.0003955342,0.0006755778,0.002989717,0.0001470312,0.00004097225,0.00003624075,0.00004689034,0.04623064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07974293,"threshold_uncertainty_score":0.9992925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00791102320093601,"score_gpt":0.2401238717204727,"score_spread":0.2322128485195367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}