{"id":"W3120635680","doi":"10.1038/s41467-020-20282-1","title":"ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; National Research Foundation Singapore; National Medical Research Council; Medical Research Council; National Research Foundation","keywords":"CTCF; Enhancer; Biology; Chromatin; Cell biology; Transcription factor; Regulation of gene expression; Promoter; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322659,0.0002567708,0.0002149232,0.0001989525,0.0001551929,0.0002261942,0.0002879169,0.0002904753,0.001026607],"category_scores_gemma":[0.0001997343,0.0002190338,0.0002437211,0.00008316857,0.0002489566,0.0001053239,0.0003436587,0.0004913437,0.0005840581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000327948,"about_ca_system_score_gemma":0.0001610057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007413593,"about_ca_topic_score_gemma":0.00124548,"domain_scores_codex":[0.9998127,0.00002026652,0.00001265415,0.00003247389,0.00008217303,0.00003986773],"domain_scores_gemma":[0.9997066,0.00005131277,0.00009094767,0.00003203345,0.0000246425,0.00009448102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002369235,0.000004186712,0.0001155418,0.00000438906,8.567728e-7,0.00002141195,0.000003416329,0.00002831927,0.9995393,0.00003258024,0.000005552669,0.0002208284],"study_design_scores_gemma":[0.000008709689,0.00005339612,0.007345889,0.000002987481,0.000004214663,0.0001976066,0.000009363882,0.001000827,0.9906908,0.00005707268,0.0006261357,0.00000295842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956952,0.0002850915,0.00325295,0.0000249419,0.000005356821,0.000008745307,0.0001409836,0.00009558179,0.0004911674],"genre_scores_gemma":[0.9973633,0.00005513553,0.001261119,0.00001634833,0.000002234719,0.00000929091,0.0003934531,0.00003417572,0.0008650151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001026607,"threshold_uncertainty_score":0.0034343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063080050065561,"score_gpt":0.2567303566932789,"score_spread":0.2460995561926233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}