{"id":"W3120660728","doi":"10.1080/21688370.2020.1860616","title":"Function of Multidrug Resistance Transporters is Disrupted by Infection Mimics in Human Brain Endothelial Cells","year":2021,"lang":"en","type":"article","venue":"Tissue Barriers","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Abcg2; Lipopolysaccharide; Blood–brain barrier; Tumor necrosis factor alpha; Biology; Transporter; P-glycoprotein; Proinflammatory cytokine; Inflammation; In vitro; Western blot; Intracellular; Pharmacology; Immunology; Multiple drug resistance; ATP-binding cassette transporter; Cell biology; Drug resistance; Microbiology; Biochemistry; Endocrinology; Central nervous system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001648551,0.0001556677,0.0003006115,0.0001026499,0.0001664228,0.0004039045,0.000109567,0.0002587363,0.0008938007],"category_scores_gemma":[0.0002108726,0.0001469421,0.0002448913,0.0001851883,0.00012052,0.0002197769,0.0001502492,0.0004800373,0.0003645911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002318508,"about_ca_system_score_gemma":0.0001702829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009926528,"about_ca_topic_score_gemma":0.0007386637,"domain_scores_codex":[0.9996856,0.00007748241,0.00003584949,0.00005656379,0.00007679363,0.00006773001],"domain_scores_gemma":[0.9999059,0.00001478855,0.00002646151,0.00001721707,0.00002404901,0.00001148474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002136934,0.00004731255,0.0003958894,0.0000457717,0.000009996518,0.0001175451,0.00004869497,0.00007670883,0.9976298,0.0001098689,0.0001132353,0.001191541],"study_design_scores_gemma":[0.00002721776,0.0007274997,0.01383234,0.0000113281,0.00003245468,0.0006812876,0.0001466853,0.002254409,0.9783303,0.00008842775,0.003855719,0.00001250718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952944,0.001384201,0.001723275,0.0001433051,0.00002735736,0.00001863995,0.0004961189,0.00004469458,0.0008679256],"genre_scores_gemma":[0.9956408,0.000784262,0.001495572,0.00007419669,0.000006157416,0.00004713,0.0009121515,0.000007457184,0.001032246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009926528,"threshold_uncertainty_score":0.002990067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00665202975103896,"score_gpt":0.2485655312775862,"score_spread":0.2419135015265472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}