{"id":"W3120676561","doi":"10.1186/s12864-021-08185-x","title":"Gene regulatory network analysis defines transcriptome landscape with alternative splicing of human umbilical vein endothelial cells during replicative senescence","year":2021,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"BC Cancer Agency; Takeda Pharmaceutical Company","keywords":"Biology; Transcriptome; Senescence; Cell biology; Alternative splicing; RNA splicing; Gene regulatory network; Spliceosome; Genetics; Gene; Gene expression; Exon; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001485842,0.0001770209,0.0002495442,0.0008427387,0.0001881837,0.0003129095,0.0001476431,0.0001422725,0.000740921],"category_scores_gemma":[0.0003900842,0.00008860311,0.0003467033,0.001086436,0.0001404362,0.0001908101,0.0001869212,0.0001505647,0.0001137532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003347014,"about_ca_system_score_gemma":0.0002473722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001596837,"about_ca_topic_score_gemma":0.001974378,"domain_scores_codex":[0.9998722,0.00002118768,0.000006482888,0.00005553536,0.00002122934,0.00002338486],"domain_scores_gemma":[0.9998444,0.00005199089,0.00005002662,0.000009896183,0.00002737445,0.0000161894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001207842,0.0001803956,0.2640176,0.0008912695,0.00062934,0.0008877767,0.0007643419,0.07387913,0.5554111,0.006152839,0.002384723,0.09359362],"study_design_scores_gemma":[0.00002644682,0.0002741985,0.5959271,0.00005361039,0.0003382621,0.0006287449,0.0004240965,0.3482373,0.04111616,0.007551018,0.00537583,0.00004720446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837635,0.0006588101,0.01175662,0.00005828916,0.000006485653,0.0000179612,0.002670481,0.0001283205,0.0009396235],"genre_scores_gemma":[0.9906216,0.000326659,0.00474951,0.00002300303,0.00000557881,0.00004377019,0.003824759,0.00001727214,0.0003879721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001596837,"threshold_uncertainty_score":0.00317502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794745890201008,"score_gpt":0.2476417634931772,"score_spread":0.2296943045911671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}