{"id":"W3120676907","doi":"10.1200/po.20.00214","title":"Revisiting Risk and Benefit in Early Oncology Trials in the Era of Precision Medicine: A Systematic Review and Meta-Analysis of Phase I Trials of Targeted Single-Agent Anticancer Therapies","year":2021,"lang":"en","type":"review","venue":"JCO Precision Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Allison University; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Medicine; Clinical trial; Internal medicine; Oncology; Adverse effect; Meta-analysis; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1046678,0.003434459,0.02953953,0.01266175,0.0007731332,0.005984705,0.003417539,0.003140568,0.002914045],"category_scores_gemma":[0.2118931,0.002510784,0.03662706,0.01163456,0.00186723,0.004567746,0.002583037,0.002652411,0.0003161833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004041698,"about_ca_system_score_gemma":0.005719439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003321879,"about_ca_topic_score_gemma":0.007412639,"domain_scores_codex":[0.8646914,0.0784741,0.04117992,0.006997196,0.007655,0.001002432],"domain_scores_gemma":[0.7125484,0.2344798,0.0364009,0.008110386,0.00759801,0.0008625786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001330969,0.00001937468,0.004448264,0.4037432,0.5779525,0.0001165127,0.0001295618,0.0004483417,0.0001458125,0.0003275454,0.0005025465,0.01083536],"study_design_scores_gemma":[0.001350828,0.0002432577,0.00461728,0.06692952,0.9218085,0.0001282654,0.00009750518,0.000358178,0.0001801319,0.001174192,0.003068441,0.00004379757],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003224114,0.9926332,0.001896606,0.0004555444,0.0002775229,0.0007113112,0.0005224245,0.00002863798,0.0002506969],"genre_scores_gemma":[0.3659415,0.607875,0.01214578,0.004074058,0.001032995,0.006801724,0.001577784,0.0001450614,0.0004061245],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1046678,"threshold_uncertainty_score":0.5535429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7534315246724375,"score_gpt":0.6499043875348117,"score_spread":0.1035271371376257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}