{"id":"W3120691235","doi":"10.3390/cells10010097","title":"Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Metformin; Mitochondrion; Cancer research; Hypoxia (environmental); Biology; Colorectal cancer; Cancer cell; Mitochondrial DNA; Cancer; Endocrinology; Cell biology; Gene; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009532951,0.0001468791,0.0002141059,0.00002290891,0.00003863395,0.00004415402,0.00006220547,0.0001395049,0.00003291707],"category_scores_gemma":[0.00003232312,0.0001453629,0.00002978105,0.00006584094,0.00006281937,0.000005799405,0.0001636313,0.00007226896,0.000001944594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001705126,"about_ca_system_score_gemma":0.00005137182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007472909,"about_ca_topic_score_gemma":0.0007855966,"domain_scores_codex":[0.998976,0.00006461974,0.000160596,0.0004747519,0.00008755663,0.0002364934],"domain_scores_gemma":[0.9995148,0.00002066943,0.00003278023,0.0002419818,0.00004345788,0.0001463705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007137306,0.00008067192,0.007767997,0.00008438214,0.00001548945,0.000009654757,0.0001522648,0.000002288825,0.9786882,0.000007792875,0.001469297,0.01165055],"study_design_scores_gemma":[0.001402899,0.00008021932,0.006677112,0.00001314979,0.00002664817,0.00000303409,0.0001435066,0.00002579974,0.9495796,0.00002941297,0.04183758,0.0001810146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9232802,0.07585768,0.00001919108,0.00001685831,0.0003036893,0.0001983562,0.00008057079,0.000002962017,0.0002405453],"genre_scores_gemma":[0.9902363,0.008021014,0.0003801683,0.0002800419,0.0002123071,0.00001701263,0.00002747606,0.00001566286,0.0008099945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06783666,"threshold_uncertainty_score":0.5927728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005546774072653345,"score_gpt":0.2219134719964186,"score_spread":0.2163666979237653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}