{"id":"W3120691235","doi":"10.3390/cells10010097","title":"Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Metformin; Mitochondrion; Cancer research; Hypoxia (environmental); Biology; Colorectal cancer; Cancer cell; Mitochondrial DNA; Cancer; Endocrinology; Cell biology; Gene; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152286,0.0001623246,0.0001556645,0.0001772156,0.000162383,0.0002090445,0.0001322832,0.0002321293,0.001199523],"category_scores_gemma":[0.0001177035,0.00009955785,0.0001472223,0.0001821567,0.0001859889,0.0001440621,0.0001449189,0.0002835249,0.0003034336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000369081,"about_ca_system_score_gemma":0.0001996385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002051296,"about_ca_topic_score_gemma":0.003114549,"domain_scores_codex":[0.9999166,0.000009838016,0.000008069966,0.00001746539,0.00002588077,0.00002212638],"domain_scores_gemma":[0.9999324,0.00001001894,0.00002293477,0.000008155121,0.000009559541,0.00001703779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009621395,0.00001495145,0.0002461665,0.00001161537,0.000002102791,0.00004229518,0.000009698312,0.00008299604,0.9986005,0.0001114371,0.00004450999,0.0007374581],"study_design_scores_gemma":[0.00002102606,0.0001763697,0.01064824,0.000004361941,0.00001018833,0.0002997492,0.00005160991,0.001582108,0.983981,0.00006914275,0.003149353,0.000006927121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955043,0.0007610078,0.001451995,0.0001236278,0.00001406431,0.00001691883,0.0005102888,0.00004446458,0.001573244],"genre_scores_gemma":[0.9965929,0.000411189,0.0006272192,0.00003762534,0.00000293964,0.00001372203,0.0005042548,0.00001243155,0.00179758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002051296,"threshold_uncertainty_score":0.004078686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005546774072653345,"score_gpt":0.2219134719964186,"score_spread":0.2163666979237653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}