{"id":"W3120693979","doi":"10.1085/jgp.202012646","title":"Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites","year":2020,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bioinformatics Solutions (Canada)","funders":"National Cancer Institute; National Institutes of Health; Gyeonggi-do Regional Research Center; Société Française de Cardiologie; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; Fondation Lefoulon Delalande; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Institute of Clinical and Translational Sciences; Deutsche Forschungsgemeinschaft; National Heart, Lung, and Blood Institute","keywords":"Phosphorylation; Gating; Cell biology; Nav1.5; Sodium channel; Biology; Protein phosphorylation; Chemistry; Biophysics; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001668407,0.00006832958,0.0001346158,0.00002369606,0.00004958734,0.000002844102,0.00005263296,0.00006156447,0.00001424917],"category_scores_gemma":[0.00003804641,0.00004703542,0.00006984645,0.00005590923,0.00006277138,0.000005400588,0.00003780917,0.00007348813,0.000001397534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004559813,"about_ca_system_score_gemma":0.00002857385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002583472,"about_ca_topic_score_gemma":1.351767e-7,"domain_scores_codex":[0.9994814,0.00009715097,0.0001992188,0.00007583939,0.00007373557,0.00007261413],"domain_scores_gemma":[0.9995385,0.00000922297,0.0002214354,0.00005892285,0.0001334876,0.00003846924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004128472,0.000008327093,0.0001408436,0.0000108713,0.00005468825,5.557194e-8,0.000148104,0.004683458,0.9916742,0.00002566233,0.002498152,0.0003428282],"study_design_scores_gemma":[0.0006914242,0.0009800725,0.08086095,0.00001102319,0.00004629083,0.00002836186,0.000247902,0.00673206,0.9060966,0.0005369008,0.003632362,0.0001359982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958053,0.000561813,0.002503429,0.0007459265,0.0002696875,0.00007743013,0.000003827838,0.000001888199,0.00003069315],"genre_scores_gemma":[0.9979318,0.0002409724,0.0001175433,0.0003209739,0.001266457,0.000001320954,0.00002271379,0.000006462661,0.00009171571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08557751,"threshold_uncertainty_score":0.1918049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02084022545205585,"score_gpt":0.2213368354545419,"score_spread":0.2004966100024861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}