{"id":"W3120693979","doi":"10.1085/jgp.202012646","title":"Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites","year":2020,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bioinformatics Solutions (Canada)","funders":"National Cancer Institute; National Institutes of Health; Gyeonggi-do Regional Research Center; Société Française de Cardiologie; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; Fondation Lefoulon Delalande; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Institute of Clinical and Translational Sciences; Deutsche Forschungsgemeinschaft; National Heart, Lung, and Blood Institute","keywords":"Phosphorylation; Gating; Cell biology; Nav1.5; Sodium channel; Biology; Protein phosphorylation; Chemistry; Biophysics; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444907,0.0002729284,0.000202005,0.0004163268,0.0002230458,0.0002618336,0.0001894326,0.0002376702,0.0007136883],"category_scores_gemma":[0.00016866,0.0001626413,0.0002917662,0.0002747644,0.0001509203,0.0002485325,0.0002172503,0.0002747524,0.0002975372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001768315,"about_ca_system_score_gemma":0.0001836261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000629638,"about_ca_topic_score_gemma":0.001095478,"domain_scores_codex":[0.9999063,0.000009523075,0.000007629272,0.00003107275,0.00002567594,0.00001981022],"domain_scores_gemma":[0.9999251,0.00001085579,0.00001989186,0.000007341175,0.00001278402,0.00002396172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005604272,0.000008256799,0.0005760715,0.00003210914,0.000007007768,0.00003038438,0.00001037252,0.00003846811,0.9983896,0.00005251903,0.00002111643,0.0007779974],"study_design_scores_gemma":[0.00003413064,0.0003052597,0.2319365,0.00002833039,0.0001271684,0.001813302,0.0002053573,0.005175789,0.7560756,0.0003843533,0.003882736,0.00003141975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926353,0.001551501,0.003938272,0.00007026402,0.0000182237,0.00001930196,0.0008768989,0.00002318074,0.0008671561],"genre_scores_gemma":[0.9831653,0.001559058,0.01060839,0.0001025895,0.00002536627,0.00003473496,0.002803637,0.00003021091,0.001670761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007136883,"threshold_uncertainty_score":0.002387464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02084022545205585,"score_gpt":0.2213368354545419,"score_spread":0.2004966100024861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}