{"id":"W3120757685","doi":"10.1038/s41467-020-20604-3","title":"Granzyme B inhibition reduces disease severity in autoimmune blistering diseases","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Autoimmune Bullous Skin Diseases","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia Hospital; University of British Columbia; SKiN Health; International Collaboration On Repair Discoveries; Vancouver Coastal Health Research Institute","funders":"Canadian Institutes of Health Research; International Collaboration on Repair Discoveries; Michael Smith Health Research BC; Government of Canada","keywords":"Granzyme B; Autoimmune disease; Disease; Immunology; Medicine; Biology; Immune system; Internal medicine; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001230893,0.0002023241,0.0003368365,0.0001840074,0.0002713609,0.00006159515,0.0003894648,0.0001864639,0.0001576013],"category_scores_gemma":[0.001194525,0.0002132959,0.0001911507,0.0007864483,0.0002250551,0.0002211822,0.0006127159,0.0009372501,0.00003400727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978232,"about_ca_system_score_gemma":0.0005517734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003133207,"about_ca_topic_score_gemma":0.0001247486,"domain_scores_codex":[0.9984418,0.0002313153,0.0004110826,0.0003412342,0.0003019627,0.0002725713],"domain_scores_gemma":[0.9966875,0.0002019246,0.0001115035,0.002509506,0.0002695463,0.0002200529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001699049,0.0191038,0.8157164,0.00130337,0.0005555931,0.003002023,0.002211073,0.0001397565,0.07282793,0.02627713,0.03276774,0.02439615],"study_design_scores_gemma":[0.0009789816,0.00001469878,0.9738045,0.000512327,0.0001790304,0.000054743,0.0001878728,0.0003969741,0.0008896839,0.0007581989,0.02199454,0.0002283876],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8693087,0.101756,0.00001898681,0.02380413,0.000226975,0.000541396,0.0001971437,0.0003533323,0.003793275],"genre_scores_gemma":[0.9931402,0.001898425,0.00136398,0.001144364,0.00005263124,0.0001303729,0.001706,0.00003667645,0.0005273944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1580882,"threshold_uncertainty_score":0.8697955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01977236917559459,"score_gpt":0.3108097490182854,"score_spread":0.2910373798426908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}