{"id":"W3120762029","doi":"10.3390/metabo11010052","title":"Beyond Proteostasis: Lipid Metabolism as a New Player in ER Homeostasis","year":2021,"lang":"en","type":"review","venue":"Metabolites","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Proteostasis; Unfolded protein response; Endoplasmic reticulum; Cell biology; Lipid metabolism; Biology; Membrane protein; Caenorhabditis elegans; Chemistry; Biochemistry; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002478599,0.0008333009,0.002242189,0.0002796483,0.00006783847,0.0001555901,0.0005437119,0.0006287289,0.000409255],"category_scores_gemma":[0.0008902258,0.0006856131,0.001117169,0.0005597751,0.00008209488,0.00001086128,0.0003988844,0.000405077,0.0001394954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002453309,"about_ca_system_score_gemma":0.001646143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001304778,"about_ca_topic_score_gemma":0.00003262722,"domain_scores_codex":[0.996448,0.0004167642,0.0008859978,0.001188637,0.0003609007,0.000699691],"domain_scores_gemma":[0.9978386,0.00005220071,0.0003392166,0.001097052,0.0001062264,0.0005666655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002825934,0.0002010421,0.00003037624,0.002587059,0.0005906185,0.00009963051,0.00004191358,0.000001960862,0.0001751552,0.001020096,0.01002708,0.9851968],"study_design_scores_gemma":[0.0006038435,0.00003313794,0.00001470186,0.001484246,0.001174306,0.00005585044,0.00003684232,3.029778e-7,0.002642325,0.0001277038,0.9930899,0.000736861],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004973219,0.9951909,0.00001316831,0.0000631204,0.0004614075,0.001003811,0.000405422,0.00002478548,0.002340096],"genre_scores_gemma":[0.00005273885,0.9921451,0.0009341699,0.0003404996,0.001252,0.0004956481,0.00163462,0.0001316849,0.003013583],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9844599,"threshold_uncertainty_score":0.9995595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205877768693203,"score_gpt":0.3103026868592631,"score_spread":0.2897149099899428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}