{"id":"W3120762029","doi":"10.3390/metabo11010052","title":"Beyond Proteostasis: Lipid Metabolism as a New Player in ER Homeostasis","year":2021,"lang":"en","type":"review","venue":"Metabolites","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Proteostasis; Unfolded protein response; Endoplasmic reticulum; Cell biology; Lipid metabolism; Biology; Membrane protein; Caenorhabditis elegans; Chemistry; Biochemistry; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005116867,0.0008987319,0.001178388,0.002069016,0.0003755324,0.001557922,0.000857354,0.001865313,0.003817838],"category_scores_gemma":[0.0006140033,0.0002221921,0.0004517398,0.002075847,0.000738444,0.002579967,0.001003966,0.00241237,0.002910278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009578399,"about_ca_system_score_gemma":0.001359812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007026902,"about_ca_topic_score_gemma":0.0009889695,"domain_scores_codex":[0.9998198,0.00003252223,0.00002165208,0.00003761562,0.00006399064,0.00002434163],"domain_scores_gemma":[0.9997055,0.0001183229,0.0000285922,0.00001488863,0.00008759917,0.00004506566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001094748,0.00005688661,0.0001733578,0.01339555,0.000110287,0.000398455,0.0001173539,0.0004644768,0.004135966,0.01893122,0.05430361,0.9078034],"study_design_scores_gemma":[0.000005709199,0.00004414107,0.0002522947,0.00138181,0.00003668145,0.0007019299,0.00003659829,0.00005696242,0.0004183161,0.003568259,0.9934852,0.00001220366],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008836832,0.9973683,0.0002862872,0.0006171201,0.0004022559,0.000002650073,0.00001821258,0.00001577534,0.001200976],"genre_scores_gemma":[0.0007313738,0.9971755,0.00026563,0.0004181634,0.000362847,0.00000491038,0.00003425673,0.000003793637,0.001003567],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003817838,"threshold_uncertainty_score":0.0127719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205877768693203,"score_gpt":0.3103026868592631,"score_spread":0.2897149099899428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}