{"id":"W3120765402","doi":"10.1016/j.chembiol.2020.12.006","title":"Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A","year":2021,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; McGill University","funders":"National Research Council Canada; National Institute of General Medical Sciences; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Worldwide Cancer Research; National Institutes of Health; University of Saskatchewan","keywords":"eIF4A; RNA; Helicase; Eukaryotic translation; Biology; RNA Helicase A; Eukaryotic initiation factor; Desmethyl; Stereochemistry; Translation (biology); Biochemistry; Chemistry; Non-coding RNA; Ribosome; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001083416,0.000184233,0.0002554735,0.00001356855,0.00008590213,0.00001883443,0.0003335489,0.0002577356,0.0003869052],"category_scores_gemma":[0.0001605288,0.0001113979,0.0001793468,0.0001489065,0.0002737608,0.000002343928,0.0002843186,0.0001840657,0.0000042974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001766775,"about_ca_system_score_gemma":0.00004886624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003070124,"about_ca_topic_score_gemma":0.00003623114,"domain_scores_codex":[0.9987441,0.0001382746,0.0003057095,0.0004580169,0.00009788247,0.0002560266],"domain_scores_gemma":[0.9991852,0.00006950058,0.00009712167,0.000422881,0.0001212304,0.0001040449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001128269,0.0000949865,0.0002328707,0.00000996403,0.00006831774,4.901204e-7,0.00002242296,0.000004141359,0.9867599,0.000009922803,0.01144906,0.001235116],"study_design_scores_gemma":[0.0002813045,0.0000730487,0.0001849483,0.000003680088,0.00004282278,0.00001206344,0.00006111136,0.00001867614,0.9531112,0.0001587576,0.04591039,0.0001419874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997388,0.0005974574,0.0002913369,0.0009891619,0.00009011745,0.00008441415,0.0003570395,0.000006010253,0.0001964809],"genre_scores_gemma":[0.9965706,0.00002063206,0.0002459175,0.0009795106,0.0004889136,0.000008029499,0.001466922,0.00001445413,0.0002050106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03446133,"threshold_uncertainty_score":0.4542674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103611761535679,"score_gpt":0.2311053678656534,"score_spread":0.2200692502502966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}