{"id":"W3120793202","doi":"10.3390/curroncol28010038","title":"Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Pediatric Patients","year":2021,"lang":"en","type":"article","venue":"Current Oncology","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal; University of Calgary; Children's Hospital of Eastern Ontario; University of British Columbia; Hospital for Sick Children; SickKids Foundation; BC Children's Hospital; University of Toronto; Centre Hospitalier Universitaire Sainte-Justine","funders":"Bayer Canada","keywords":"Trk receptor; Medicine; Tolerability; Fusion gene; Cancer research; Cancer; Pediatric cancer; Targeted therapy; Oncology; Internal medicine; Receptor tyrosine kinase; Tyrosine-kinase inhibitor; Tyrosine kinase; Neurotrophin; Receptor; Adverse effect; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01013109,0.0006937463,0.001327876,0.002915509,0.002407056,0.002418087,0.005015,0.004307221,0.00528424],"category_scores_gemma":[0.02285249,0.0006088965,0.002477409,0.002402609,0.001798249,0.001404801,0.002555657,0.005735392,0.0034355],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01476864,"about_ca_system_score_gemma":0.07877751,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3845449,"about_ca_topic_score_gemma":0.5279835,"domain_scores_codex":[0.989598,0.002806901,0.001920951,0.0006771192,0.003874419,0.001122514],"domain_scores_gemma":[0.9610237,0.002636474,0.0016798,0.000835442,0.03008441,0.003740102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001805727,0.00006323103,0.01257431,0.001544126,0.0001351223,0.002027684,0.0005162798,0.001295863,0.002972997,0.009051932,0.6840487,0.2855892],"study_design_scores_gemma":[0.00009695207,0.00007183365,0.01319881,0.004014583,0.0001281074,0.003288579,0.0003358058,0.0006712069,0.00159776,0.002533094,0.9739683,0.00009488798],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.01236108,0.2161433,0.05150608,0.4802933,0.01529437,0.002622143,0.01047956,0.002100572,0.2091997],"genre_scores_gemma":[0.1770156,0.2131565,0.2531288,0.2531527,0.006637526,0.003531505,0.02945665,0.001563064,0.06235759],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.9852313,"threshold_uncertainty_score":0.7646132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1335528570273636,"score_gpt":0.3839484428254468,"score_spread":0.2503955857980832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}