{"id":"W3120793202","doi":"10.3390/curroncol28010038","title":"Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Pediatric Patients","year":2021,"lang":"en","type":"article","venue":"Current Oncology","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal; University of Calgary; Children's Hospital of Eastern Ontario; University of British Columbia; Hospital for Sick Children; SickKids Foundation; BC Children's Hospital; University of Toronto; Centre Hospitalier Universitaire Sainte-Justine","funders":"Bayer Canada","keywords":"Trk receptor; Medicine; Tolerability; Fusion gene; Cancer research; Cancer; Pediatric cancer; Targeted therapy; Oncology; Internal medicine; Receptor tyrosine kinase; Tyrosine-kinase inhibitor; Tyrosine kinase; Neurotrophin; Receptor; Adverse effect; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003822134,0.00007755497,0.0002553592,0.0001280904,0.00003049247,0.000002614565,0.00001275025,0.00005002484,0.0000260337],"category_scores_gemma":[0.0002450454,0.00006544482,0.00003277682,0.0001684914,0.00002353963,0.000007165255,0.00001104635,0.00003071315,5.88679e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588934,"about_ca_system_score_gemma":0.0008049062,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003715535,"about_ca_topic_score_gemma":0.02626517,"domain_scores_codex":[0.9993571,0.00004028616,0.0002094724,0.0001770236,0.0000474215,0.0001687041],"domain_scores_gemma":[0.9992867,0.0002979699,0.0000658143,0.00007471508,0.0001436328,0.0001312369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006843937,0.0003691087,0.8302542,0.00009259998,0.000006561599,0.00006484809,0.00006985385,3.519169e-7,0.000672962,0.000005429927,0.0005101791,0.1678855],"study_design_scores_gemma":[0.003863844,0.001145958,0.9813014,0.00005617864,0.0001008091,0.00003195557,0.00003600176,0.0002233278,0.0005950434,0.00001225404,0.0125692,0.00006405194],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949548,0.00338472,3.51221e-7,0.0004940103,0.0004771759,0.0003448174,0.000115287,0.000004713785,0.0002241631],"genre_scores_gemma":[0.9991265,0.0004384405,0.0002182437,0.00002791417,0.00007002513,0.00005429744,0.00002926978,0.000007668296,0.00002762051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1678214,"threshold_uncertainty_score":0.9915029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1335528570273636,"score_gpt":0.3839484428254468,"score_spread":0.2503955857980832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}