{"id":"W3120817929","doi":"10.1001/jamaneurol.2020.4986","title":"Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease","year":2021,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":324,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wallenberg Centre for Molecular and Translational Medicine; Canadian Institutes of Health Research; Genentech; UK Dementia Research Institute; Julius Clinical; IXICO; H. Lundbeck A/S; Orionin Tutkimussäätiö; Eisai; Vetenskapsrådet; European Commission; Hjärnfonden; University of Southern California; University College London; Northern California Institute for Research and Education; Ministerio de Ciencia, Innovación y Universidades; Instituto de Salud Carlos III; Siemens Healthineers; EU Joint Programme – Neurodegenerative Disease Research; Servier; Knut och Alice Wallenbergs Stiftelse; Biogen; BioClinica; National Institutes of Health; Rosetrees Trust; BrightFocus Foundation; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Gun och Bertil Stohnes Stiftelse; Bristol-Myers Squibb; Alzheimer's Association","keywords":"Neurodegeneration; Dementia; Medicine; Magnetic resonance imaging; Cognitive decline; Alzheimer's disease; Internal medicine; Pathology; Oncology; Psychology; Disease; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001182495,0.0002603398,0.0002560347,0.0004506823,0.0003897305,0.0004188346,0.0003571722,0.0004581593,0.0007597242],"category_scores_gemma":[0.00248097,0.0002972846,0.000296107,0.0006721478,0.0001653976,0.0003910844,0.0002988068,0.0006220521,0.0001471183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002562932,"about_ca_system_score_gemma":0.0002923746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00412914,"about_ca_topic_score_gemma":0.003779792,"domain_scores_codex":[0.9996514,0.00009495517,0.00003060854,0.0001194977,0.0000472857,0.00005620486],"domain_scores_gemma":[0.9986393,0.0001943606,0.0006500069,0.0001343298,0.0001815538,0.0002005184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003206233,0.00004420807,0.9982817,0.000006400951,0.0000674956,0.00003403774,0.00004619197,0.00002559138,0.0003711932,0.000009261586,0.00006621353,0.0007271187],"study_design_scores_gemma":[0.00001030678,0.0001230108,0.9994248,0.000003204753,0.00003348745,0.00008707939,0.00004104538,0.0001091282,0.00006137847,0.00002238195,0.00008211663,0.000002029001],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991382,0.0002632336,0.00008480562,0.00002988209,0.000004645154,0.000005559967,0.0003499556,0.000003013768,0.0001206498],"genre_scores_gemma":[0.9991508,0.0001030086,0.0001348539,0.00002499404,0.000009226379,0.00001288938,0.0004215645,0.000001600484,0.0001411804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00412914,"threshold_uncertainty_score":0.008210242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010259912447042,"score_gpt":0.2796995654236327,"score_spread":0.2595969662991622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}