{"id":"W3120817929","doi":"10.1001/jamaneurol.2020.4986","title":"Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease","year":2021,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":324,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wallenberg Centre for Molecular and Translational Medicine; Canadian Institutes of Health Research; Genentech; UK Dementia Research Institute; Julius Clinical; IXICO; H. Lundbeck A/S; Orionin Tutkimussäätiö; Eisai; Vetenskapsrådet; European Commission; Hjärnfonden; University of Southern California; University College London; Northern California Institute for Research and Education; Ministerio de Ciencia, Innovación y Universidades; Instituto de Salud Carlos III; Siemens Healthineers; EU Joint Programme – Neurodegenerative Disease Research; Servier; Knut och Alice Wallenbergs Stiftelse; Biogen; BioClinica; National Institutes of Health; Rosetrees Trust; BrightFocus Foundation; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Gun och Bertil Stohnes Stiftelse; Bristol-Myers Squibb; Alzheimer's Association","keywords":"Neurodegeneration; Dementia; Medicine; Magnetic resonance imaging; Cognitive decline; Alzheimer's disease; Internal medicine; Pathology; Oncology; Psychology; Disease; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438721,0.0001109536,0.0002210659,0.000126738,0.00004218977,0.00001951058,0.00003652063,0.00006942747,0.0001045684],"category_scores_gemma":[0.0001712942,0.0000975761,0.00003437386,0.0003089432,0.00006158745,0.00006911456,0.0000593514,0.0002929508,0.000003451729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005615213,"about_ca_system_score_gemma":0.0001569654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000221433,"about_ca_topic_score_gemma":0.00006063965,"domain_scores_codex":[0.9987257,0.000217871,0.0002232052,0.0003419689,0.0002536877,0.0002376102],"domain_scores_gemma":[0.9993436,0.00007887286,0.00007380346,0.0001653083,0.0002008079,0.0001376493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006516673,0.0007233247,0.9695287,0.0000195201,0.0001149468,0.001760609,0.00006641935,0.00001619201,0.02576284,0.0001711417,0.0001193562,0.001065272],"study_design_scores_gemma":[0.002947778,0.001118256,0.9624276,0.00001344619,0.0003652612,0.00009038782,0.000009985568,0.0004316317,0.03227409,0.00002819315,0.0002258056,0.00006759407],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851173,0.0006840232,0.00001609969,0.01329441,0.00004791664,0.0003152545,0.00001269315,0.00001524609,0.0004971234],"genre_scores_gemma":[0.9978418,0.0001297175,0.00003453813,0.001716966,0.00004797668,0.00003707447,0.00007253744,0.00001498167,0.0001044114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01272457,"threshold_uncertainty_score":0.3979038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010259912447042,"score_gpt":0.2796995654236327,"score_spread":0.2595969662991622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}