{"id":"W3120833111","doi":"10.1158/1078-0432.ccr-20-3708","title":"<i>BRCA2</i> , <i>ATM</i> , and <i>CDK12</i> Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Alberta Cancer Foundation; BC Cancer Agency; Spinal Cord Injury BC; University of British Columbia","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada; Government of Canada; Prostate Cancer Foundation","keywords":"Biology; Prostate cancer; Cancer research; Context (archaeology); Cancer; Genome instability; Allele; PTEN; Primary tumor; Chromoplexy; Mutation; Copy-number variation; Genetics; DNA damage; Gene; Metastasis; Genome; DNA; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001843311,0.0002089929,0.0002060011,0.0005394095,0.0001192339,0.0004247803,0.000205525,0.0002372561,0.001968532],"category_scores_gemma":[0.0004061708,0.0001386438,0.0001313196,0.0003318036,0.000271803,0.0001479217,0.0001794872,0.0002695416,0.0003740626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021578,"about_ca_system_score_gemma":0.0001717668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005159259,"about_ca_topic_score_gemma":0.0006643963,"domain_scores_codex":[0.999841,0.00001991485,0.000009472926,0.00006944829,0.00003250822,0.00002771368],"domain_scores_gemma":[0.9996856,0.00006108508,0.0001386116,0.00002546869,0.0000234759,0.00006578462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001594255,0.00009284163,0.3584373,0.00008366603,0.00009485298,0.0006307706,0.0001392668,0.0005848336,0.6202496,0.0002160028,0.0004703155,0.01740624],"study_design_scores_gemma":[0.00001894408,0.0003162334,0.9237263,0.000009304238,0.00008135607,0.004049637,0.0001265414,0.0016229,0.0687331,0.000192677,0.001112028,0.00001086368],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984263,0.0001628684,0.0005066315,0.00002333559,0.000001587532,0.000006355622,0.0003498434,0.00003846842,0.0004847067],"genre_scores_gemma":[0.9991302,0.00005887316,0.0002953055,0.00002013107,0.000002562279,0.000004191677,0.0003027935,0.00001620851,0.0001695507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001968532,"threshold_uncertainty_score":0.006585419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1364647966969228,"score_gpt":0.4860099415072429,"score_spread":0.3495451448103201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}