{"id":"W3120833111","doi":"10.1158/1078-0432.ccr-20-3708","title":"<i>BRCA2</i> , <i>ATM</i> , and <i>CDK12</i> Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Alberta Cancer Foundation; BC Cancer Agency; Spinal Cord Injury BC; University of British Columbia","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada; Government of Canada; Prostate Cancer Foundation","keywords":"Biology; Prostate cancer; Cancer research; Context (archaeology); Cancer; Genome instability; Allele; PTEN; Primary tumor; Chromoplexy; Mutation; Copy-number variation; Genetics; DNA damage; Gene; Metastasis; Genome; DNA; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003250598,0.0003429032,0.001009726,0.0001515499,0.0004584686,0.0002077299,0.0002308073,0.0003519981,0.0004426818],"category_scores_gemma":[0.001372123,0.0002574671,0.0002957062,0.000559298,0.001936035,0.0001557852,0.001100036,0.002300456,0.000069866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002226913,"about_ca_system_score_gemma":0.002223769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008705969,"about_ca_topic_score_gemma":0.0001863299,"domain_scores_codex":[0.9939791,0.001171267,0.001090975,0.001476809,0.001137159,0.0011447],"domain_scores_gemma":[0.994834,0.001951928,0.0001625841,0.0007215812,0.0009729653,0.001356956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004920638,0.001248473,0.7945839,0.000560486,0.0004338292,0.002295959,0.0001804963,3.195745e-7,0.008336329,0.0000735902,0.01339251,0.1739735],"study_design_scores_gemma":[0.03483855,0.00564496,0.7765776,0.003504372,0.0006548567,0.0003403365,0.0004358738,0.0009863027,0.01604078,0.001607067,0.1583449,0.00102439],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623489,0.02965768,0.000006055874,0.005185755,0.0005251064,0.001229765,0.00008962295,0.00006548625,0.0008916068],"genre_scores_gemma":[0.8150584,0.1763161,0.0003945292,0.001944117,0.001200404,0.0001901657,0.00009571306,0.0001014766,0.004699034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1729491,"threshold_uncertainty_score":0.9999878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1364647966969228,"score_gpt":0.4860099415072429,"score_spread":0.3495451448103201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}