{"id":"W3120837154","doi":"10.1016/j.celrep.2020.108565","title":"MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Institute of Allergy and Infectious Diseases; European Research Council; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Agenzia di Ricerca per la Sclerosi Laterale Amiotrofica; National Cancer Institute; Seventh Framework Programme; Ministero dell’Istruzione, dell’Università e della Ricerca; FP7 People: Marie-Curie Actions; Fondazione Cariplo; National Institute of General Medical Sciences; Fondazione Telethon; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Consiglio Nazionale delle Ricerche; Fondation SNCF; Technische Universiteit Delft; King Abdullah University of Science and Technology; Association for International Cancer Research","keywords":"Transcription bubble; Rad50; Transcription (linguistics); RNA polymerase II; Polymerase; DNA; RNA polymerase; Cell biology; Biology; Genetics; Molecular biology; Chemistry; RNA; Computational biology; RNA-dependent RNA polymerase; Transcription factor; DNA-binding protein; Gene; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003576284,0.0004001059,0.0004123952,0.0001642885,0.0001646553,0.0004606898,0.00029578,0.0003079925,0.001202186],"category_scores_gemma":[0.0004552241,0.0002735844,0.0002189229,0.00008162294,0.0004407919,0.0002453412,0.0003319277,0.0004550662,0.0006942046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005655586,"about_ca_system_score_gemma":0.0002555816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005528822,"about_ca_topic_score_gemma":0.001140659,"domain_scores_codex":[0.9996091,0.00007018386,0.00004200601,0.0001229821,0.00009617665,0.00005960723],"domain_scores_gemma":[0.9996789,0.00006751635,0.00008194378,0.00005403889,0.0000223087,0.00009539419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004952078,0.00001232143,0.0001741792,0.00002170893,0.000003664234,0.00001894796,0.000007765406,0.00004744714,0.9993005,0.0000566097,0.00002114322,0.0002861421],"study_design_scores_gemma":[0.000006842659,0.00005808488,0.002039755,0.000005065014,0.000004476079,0.00009566984,0.00001005905,0.0006469507,0.9959701,0.00002378238,0.001135419,0.000003692756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940881,0.001211109,0.003189524,0.0001152626,0.00003402388,0.00001426381,0.0001817526,0.0001244944,0.001041479],"genre_scores_gemma":[0.9952102,0.0002450119,0.00269663,0.00003414425,0.000007898279,0.00001779857,0.0006247195,0.00004060356,0.001122886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202186,"threshold_uncertainty_score":0.004103422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120947772424898,"score_gpt":0.2329713933116067,"score_spread":0.2217619155873577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}