{"id":"W3120866514","doi":"10.1038/s41467-020-20368-w","title":"A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Cancer Council Victoria; Medical Research Council; Canadian Institutes of Health Research; Northwest Regional Development Agency; Diabetes UK; National Cancer Institute; British Heart Foundation; National Institute for Health and Care Research; QIMR Berghofer Medical Research Institute; Prostate Cancer Foundation of Australia; Cancer Research Institute; Royal Marsden NHS Foundation Trust; Rosetrees Trust; European Commission; Pancreatic Cancer UK; Breast Cancer Research Foundation; Wellcome Trust; Prostate Cancer Foundation; National Cancer Research Institute; National Institutes of Health; Ovarian Cancer Research Fund; National Health and Medical Research Council; Cancer Research UK","keywords":"Mendelian randomization; Pleiotropy; Single-nucleotide polymorphism; Cancer; Vitamin D and neurology; Ovarian cancer; Confidence interval; Internal medicine; Medicine; Oncology; Bioinformatics; Biology; Genetics; Genetic variants; Gene; Phenotype; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03418512,0.00168925,0.002554008,0.00251854,0.001085383,0.001282795,0.001639929,0.0007786341,0.004515859],"category_scores_gemma":[0.07781398,0.000570079,0.003410331,0.002253214,0.001033616,0.001081369,0.001413599,0.001659389,0.0005600071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007051865,"about_ca_system_score_gemma":0.00146442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004236754,"about_ca_topic_score_gemma":0.003963443,"domain_scores_codex":[0.9518032,0.03544145,0.002188178,0.005790191,0.00414294,0.0006340944],"domain_scores_gemma":[0.9495628,0.02679623,0.003128358,0.01815582,0.002026102,0.0003307304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.008672838,0.0007733986,0.2358472,0.002925551,0.03296972,0.006757212,0.002532791,0.02476243,0.07459669,0.07641807,0.01474342,0.5190007],"study_design_scores_gemma":[0.002946563,0.01151233,0.4841195,0.00093672,0.02942402,0.0186031,0.001048795,0.1670704,0.05302336,0.1159315,0.1143863,0.0009974751],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2017934,0.002587086,0.7829405,0.0009162824,0.0005799102,0.001485702,0.002408056,0.001768038,0.005521078],"genre_scores_gemma":[0.7152683,0.0009612056,0.2774197,0.0007891776,0.0001579254,0.001175341,0.001236739,0.0005039956,0.002487665],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03418512,"threshold_uncertainty_score":0.1807904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03061956480146695,"score_gpt":0.359370327817588,"score_spread":0.3287507630161211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}